ArticleMolecular and cellular biochemistry2015
Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice.
Article in Molecular and cellular biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis.Scientific reports · 2017Trial
- Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice.bioRxiv : the preprint server for biology · 2026Article
- Review
- Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in mice.Arthritis research & therapy · 2023Article
- [Electroacupuncture improves motor function of rats with osteoarthritis by alleviating joint inflammation through the Wnt-7B/β-catenin signaling pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis.Biomolecules · 2022Review
- ADAMTS7 degrades Comp to fuel BMP2-dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas.FEBS open bio · 2020Article
- lncRNA/mRNA profiling of endometriosis rat uterine tissues during the implantation window.International journal of molecular medicine · 2019Article
- Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion.Molecular medicine reports · 2019Article
- Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- Association of serum ADAMTS-7 levels with left ventricular reverse remodeling after ST-elevation myocardial infarction.European journal of medical research · 2018Article
- VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts.Journal of cellular and molecular medicine · 2016Article
- The Function and Roles of ADAMTS-7 in Inflammatory Diseases.Mediators of inflammation · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The aim of the present study is to determine whether ADAMTS-7 contributes to the onset and severity of joint inflammation in the pathogenesis of inflammatory arthritis. ADAMTS-7 was found to be elevated in the course of collagen-induced arthritis (CIA). ADAMTS-7 transgenic (TG) mice were more susceptible to the induction of CIA. The onset of CIA was accelerated and the arthritic severity was increased in TG mice compared to wild-type mice. The overall incidence was also significantly higher in TG mice. In addition, arthritic TG mice displayed significantly higher clinical and histological arthritis scores. The COMP degradative fragments were significantly elevated in articular cartilage and sera in CIA models of TG mice. Furthermore, the production of tumor necrosis factor-alpha and interleukin-17 was also increased in serum and draining lymph nodes of arthritic TG mice. Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis, and that inhibition of ADAMTS-7 may be a potential target to ameliorate the severity of inflammatory arthritis.
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Registered trials
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