Evidence map›Paper›PMID 25742872›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015

Effects of Environmental Manipulations and Treatment with Bupropion and Risperidone on Choice between Methamphetamine and Food in Rhesus Monkeys.

Matthew L Banks, Bruce E Blough

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  10. Medications Development for Treatment of Opioid Use Disorder.Cold Spring Harbor perspectives in medicine · 2021
    Review
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  13. Article
  14. Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Matthew L Banks1] Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA [2] Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000000349495246
Bruce E BloughCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC, USA.
RTI International · USVirginia Commonwealth University · US

Funding

POTENTIAL TREATMENT MEDICATIONS FOR DRUG ABUSER01DA012970 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI BLOUGH, BRUCE E · 1999 to 2013
$5.5M
Treatment Development for Methamphetamine AbuseR01DA031718 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BANKS, MATTHEW L · 2012 to 2014
$1.1M
NIDA NIH HHS R01 DA012970NIDA NIH HHS R01DA012970NIDA NIH HHS R01 DA031718NIDA NIH HHS R01DA031718
6 · The paper itself

Abstract

Preclinical and human laboratory choice procedures have been invaluable in improving our knowledge of the neurobiological mechanisms of drug reinforcement and in the drug development process for candidate medications to treat drug addiction. However, little is known about the neuropharmacological mechanisms of methamphetamine vs food choice. The aims of this study were to develop a methamphetamine vs food choice procedure and determine treatment effects with two clinically relevant compounds: the monoamine uptake inhibitor bupropion and the dopamine antagonist risperidone. Rhesus monkeys (n=6) responded under a concurrent schedule of food delivery (1-g pellets, fixed-ratio (FR) 100 schedule) and intravenous methamphetamine injections (0-0.32 mg/kg/injection, FR10 schedule) during 7-day bupropion (0.32-1.8 mg/kg/h) and risperidone (0.001-0.0056 mg/kg/h) treatment periods. For comparison, effects of removing food pellets or methamphetamine injections and FR response requirement manipulations were also examined. Under saline treatment conditions, food was preferred over no methamphetamine or small unit methamphetamine doses (0.01-0.032 mg/kg/injection). Larger methamphetamine doses resulted in greater methamphetamine preference and 0.32 mg/kg/injection methamphetamine maintained near exclusive preference. Removing food availability increased methamphetamine choice, whereas removing methamphetamine availability decreased methamphetamine choice. Methamphetamine choice was not significantly altered when the FR response requirements for food and drug were the same (FR100:FR100 or FR10:FR10). Risperidone treatment increased methamphetamine choice, whereas bupropion treatment did not alter methamphetamine choice up to doses that decreased rates of operant behavior. Overall, these negative results with bupropion and risperidone are concordant with previous human laboratory and clinical trials and support the potential validity of this preclinical methamphetamine vs food choice model.

Indexed as

EnvironmentFoodAnimalsBupropionChoice BehaviorConditioning, OperantDopamine AgentsMacaca mulattaMaleMethamphetamineRisperidoneSelf AdministrationBupropionDopamine AgentsMethamphetamineRisperidone

Identifiers

PMID25742872
PMCPMC4613609
OpenAlexW1975271739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.