Evidence map›Paper›PMID 25742772›Full record

ArticleDiabetologia2015

Cardiac rehabilitation completion is associated with reduced mortality in patients with diabetes and coronary artery disease.

Marni J Armstrong, Ronald J Sigal, Ross Arena, Trina L Hauer, Leslie D Austford, Sandeep Aggarwal, James A Stone, Billie-Jean Martin

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03103854 (The Impact of Novel Strategies to Improve Cardiometabolic Status and Adherence to Exercise Regimens in Patients at High Risk for Cardiovascular Disease), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03103854 naunknown statusnot on this map

The Impact of Novel Strategies to Improve Cardiometabolic Status and Adherence to Exercise Regimens in Patients at High Risk for Cardiovascular Disease

TypeinterventionalSponsorCambridge Cardiac Care CentreRan2014 to 2019Enrolled500ConditionsDiabetes Mellitus, Type 2, Myocardial Infarction, Coronary Artery Disease, Atrial FibrillationArmsBURST physical activity, Text Message Reminders, Moderate Intensity Continuous Training
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
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  12. Patients who do not complete cardiac rehabilitation have an increased risk of cardiovascular events during long-term follow-up.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020
    Article
  13. Observational
  14. Observational
  15. Article
  16. Article
  17. Retinopathy and Mortality.Diabetes spectrum : a publication of the American Diabetes Association · 2018
    Article
  18. Cardiac rehabilitation in patients who underwent primary percutaneous coronary intervention for acute myocardial infarction: determinants of programme participation and completion.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2017
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Marni J ArmstrongCardiovascular and Respiratory Sciences, Cumming School of Medicine, Diabetes Clinical Trials Unit, 1820 Richmond Road SW, Calgary, AB, T2T 5C7, Canada, marni.armstrong@ucalgary.ca.
Ronald J Sigal
Ross Arena
Trina L Hauer
Leslie D Austford
Sandeep Aggarwal
James A Stone
Billie-Jean Martin
Total (Canada) · CAUniversity of Calgary · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

aimsCardiac rehabilitation (CR) reduces the risks of mortality and hospitalisation in patients with coronary artery disease and without diabetes. It is unknown whether patients with diabetes obtain the same benefits from CR.

methodsWe retrospectively examined patients referred to a 12 week CR programme between 1996 and 2010. Associations between CR completion vs non-completion and death, hospitalisation rate and cardiac hospitalisation rate were assessed by survival analysis.

resultsOver the study period, 13,158 participants were referred to CR (mean ± SD, age 59.9 ± 11.1 years, 28.9% female, 2,956 [22.5%] with diabetes). Patients with diabetes were less likely to complete CR than those without diabetes (41% vs 56%, p < .0001). Over a median follow-up of 6.6 years, there were 379 deaths in patients with diabetes vs 941 deaths among those without diabetes (12.8% vs 8.9%). Of the non-completers, patients with diabetes had a higher mortality rate compared with those without diabetes (17.7% vs 11.3%). In patients who completed CR, mortality was lower: 11.1% in patients with diabetes vs 7.0% in those without diabetes. In patients with diabetes, CR completion was associated with reduced mortality (HR 0.46 [95% CI 0.37, 0.56]), reduced hospitalisation (HR 0.86 [95% CI 0.76, 0.96]) and reduced cardiac hospitalisation (HR 0.67 [95% CI 0.54, 0.84]). The protective associations were similar to those of patients without diabetes. In multivariable adjusted analyses, all of these associations remained significant.

conclusionsPatients with diabetes were less likely to complete CR than those without diabetes. However, patients with diabetes who completed CR derived similar apparent reductions in mortality and hospitalisation to patients without diabetes.

Indexed as

AgedChi-Square DistributionCoronary Artery DiseaseDiabetes MellitusDiabetic AngiopathiesFemaleHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPatient ComplianceProportional Hazards ModelsProtective FactorsRetrospective Studies

Identifiers

PMID25742772
OpenAlexW2004189364

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.