ArticleScientific reports2015
Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Fibroblast Growth Factor 2-Immobilized Biointerfaces Drive Exogenous Transforming Growth Factor β1-Independent Chondrogenesis of Human Mesenchymal Stem Cell and Ectopic Cartilage Tissue Formation.Biomaterials research · 2026Article
- Primary Synovial Chondromatosis of the Elbow Joint Presenting with Ulnar Nerve Compression and Restricted Range of Motion: A Case Report.Journal of orthopaedic case reports · 2026Article
- Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review).Molecular medicine reports · 2026Review
- Primary Synovial Chondromatosis of the Hip Joint: A Case Report.Journal of orthopaedic case reports · 2025Article
- CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis.Cell and tissue research · 2024Article
- Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation.Communications biology · 2022Article
- Synovial chondromatosis of the temporomandibular joint with 400 loose bodies: a case report and literature review.The Journal of international medical research · 2021Review
- A Case of Synovial Chondromatosis of Temporomandibular Joint with Numerous Loose Bodies.Case reports in dentistry · 2021Article
- [Expression of cartilage oligomeric matrix protein in the synovial chondromatosis of the temporomandibular joint].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Bilateral synovial chondromatosis of the elbow in an adolescent: a case report and literature review.BMC musculoskeletal disorders · 2020Review
- Scanning electoronmicroscopical analysis of the loose bodies of synovial chondoromatosis in temporomandibular joint.Medical molecular morphology · 2020Article
- Malignant Transformation of Recurrent Synovial Chondromatosis: A Case Report and Review.Cureus · 2019Article
- Biomimetic osteochondral regeneration of the TMJ condyle: integrating BMP-2 osteoinduction, MSC-mediated fibrochondrogenesis, and gradient 3D-printed scaffolds.Journal of oral biology and craniofacial researchReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovial chondromatosis (SC) of temporomandibular joint is rare proliferative disorder featured by the formation of cartilaginous nodules in synovium and joint space. Transforming growth factor beta 3 (TGF-β3) is closely related to chondrogenic differentiation, and might participate in pathogenesis of SC. We discovered that increased quantity of synoviocytes and blood vessels were observed in SC synovium. The vessel wall and sublining fibroblasts were stained positively by the antibodies against TGF-β3, fibroblast growth factor 2 (FGF-2), and CD34. In loose bodies (LBs), TGF-β3 was mainly expressed in chondrocytes and FGF-2 was expressed in chondrocytes, fibroblasts, and vessel walls. Expressions of TGF-β1, TGF-β3, FGF-2, Sox9, Wnt-4, Foxc2, and VEGF-A mRNA were significantly higher in SC synovium. Stimulation of TGF-β3 on synoviocytes increased alkaline phosphatase (ALP) activity and expressions of chondrogenic genes (Sox9, Col2α1, Aggrecan, Wnt-4, and Wnt-11), osteogenic genes (Runx2, Foxc2, osteocalcin, and Col1α1), and VEGF-A, but failed to influence FGF-2 expression. However, the addition of FGF-2 increased TGF-β3 expression. In conclusion, TGF-β3 existed in synovium and LBs of SC, and was responsible for the pathogenesis of SC.
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