Evidence map›Paper›PMID 25742693›Full record

ArticleStem cells translational medicine2015

Peripheral blood-derived mesenchymal stem cells: candidate cells responsible for healing critical-sized calvarial bone defects.

Shaowei Li, Ke-Jung Huang, Jen-Chieh Wu, Michael S Hu, Mrinmoy Sanyal, Min Hu, Michael T Longaker, H Peter Lorenz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Mesenchymal Stem Cells in Cancer Therapy.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Stem Cells and Bone Tissue Engineering.Life (Basel, Switzerland) · 2024
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaowei LiDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA.
Ke-Jung HuangDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA.
Jen-Chieh WuDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA.
Michael S HuDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA.
Mrinmoy SanyalDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA.
Min HuDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA.
Michael T LongakerDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA.
H Peter LorenzDivision of Plastic and Reconstructive Surgery, Department of Surgery, and Department of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA plorenz@stanford.edu.

Funding

Skin Regeneration: Cellular & Molecular MechanismsR01GM087609 · NIGMS · STANFORD UNIVERSITY · PI LORENZ, HERMANN PETER · 2008 to 2012
$1.6M
NIGMS NIH HHS R01 GM087609
6 · The paper itself

Abstract

Postnatal tissue-specific stem/progenitor cells hold great promise to enhance repair of damaged tissues. Many of these cells are retrieved from bone marrow or adipose tissue via invasive procedures. Peripheral blood is an ideal alternative source for the stem/progenitor cells because of its ease of retrieval. We present a coculture system that routinely produces a group of cells from adult peripheral blood. Treatment with these cells enhanced healing of critical-size bone defects in the mouse calvarium, a proof of principle that peripheral blood-derived cells can be used to heal bone defects. From these cells, we isolated a subset of CD45(-) cells with a fibroblastic morphology. The CD45(-) cells were responsible for most of the differentiation-induced calcification activity and were most likely responsible for the enhanced healing process. These CD45(-) fibroblastic cells are plastic-adherent and exhibit a surface marker profile negative for CD34, CD19, CD11b, lineage, and c-kit and positive for stem cell antigen 1, CD73, CD44, CD90.1, CD29, CD105, CD106, and CD140α. Furthermore, these cells exhibited osteogenesis, chondrogenesis, and adipogenesis capabilities. The CD45(-) fibroblastic cells are the first peripheral blood-derived cells that fulfill the criteria of mesenchymal stem cells as defined by the International Society for Cellular Therapy. We have named these cells "blood-derived mesenchymal stem cells."

Indexed as

Cell- and Tissue-Based TherapyPeripheral Blood Stem Cell TransplantationAdipogenesisAnimalsBone RegenerationCell DifferentiationChondrogenesisHumansMesenchymal Stem CellsMiceOsteogenesisSkullCalvarial bone defectMesenchymal stem cellOsteogenesisPeripheral bloodRegeneration

Identifiers

PMID25742693
PMCPMC4367504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.