ArticleJournal of empirical research on human research ethics : JERHRE2015
Using "clinical trial diaries" to track patterns of participation for serial healthy volunteers in U.S. phase I studies.
Article in Journal of empirical research on human research ethics : JERHRE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- More than a moment: Evolving decisions among eligible volunteers in phase 1 COVID-19 vaccine trials.Human vaccines & immunotherapeutics · 2026Article
- The impact of the COVID-19 pandemic on healthy volunteer motivations: a mixed-methods study of participants in plague vaccine trials in the UK and Uganda.BMC public health · 2026Article
- "Stories like ours continue": A phenomenological exploration of the lived experiences of ex-serial clinical trial volunteers in South India.Dialogues in health · 2025Article
- Pharmacovigilance and bioethics: the importance of a neglected relationship.Frontiers in drug safety and regulation · 2025Review
- Mutual Emotional Labor as Method: Building Connections of Care in Qualitative Research.Qualitative report (Online) · 2023Article
- "Death and Taxes": Why Financial Compensation for Research Participants is an Economic and Legal Risk.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2023Article
- Why not? Motivations for entering a volunteer register for clinical trials during the COVID-19 pandemic.European journal of clinical pharmacology · 2022Article
- Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials.Ethics & human research · 2022Article
- Gendered Logics of Biomedical Research: Women in U.S. Phase I Clinical Trials.Social problems · 2022Article
- Phase I trial compensation: How much do healthy volunteers actually earn from clinical trial enrollment?Clinical trials (London, England) · 2021Article
- Healthy volunteers in US phase I clinical trials: Sociodemographic characteristics and participation over time.PloS one · 2021Article
- Speculating on Precarious Income: Finance Cultures and the Risky Strategies of Healthy Volunteers in Clinical Drug Trials.Journal of cultural economy · 2021Article
- Controlled human infection with SARS-CoV-2 to study COVID-19 vaccines and treatments: bioethics in Utopia.Journal of medical ethics · 2020Article
- Sacrificial Labour: Social Inequality, Identity Work, and the Damaging Pursuit of Elusive Futures.Work, employment & society : a journal of the British Sociological Association · 2020Article
- Disadvantaged, Outnumbered, and Discouraged: Women's Experiences as Healthy Volunteers in U.S. Phase I Trials.Critical public health · 2020Article
- Picking and Choosing Among Phase I Trials : A Qualitative Examination of How Healthy Volunteers Understand Study Risks.Journal of bioethical inquiry · 2019Article
- Informal professionalization of healthy participants in phase I clinical trials in Russia.Clinical trials (London, England) · 2019Article
- Commentary on Zvonareva et al.: Exploring the many meanings of "professional" in research participation.Clinical trials (London, England) · 2019Article
- Appraising Harm in Phase I Trials: Healthy Volunteers' Accounts of Adverse Events.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2019Article
- Advancing Ethics and Policy for Healthy-Volunteer Research through a Model-Organism Framework.Ethics & human research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Phase I testing of investigational drugs relies on healthy volunteers as research participants. Many U.S. healthy volunteers enroll repeatedly in clinical trials for the financial compensation. Serial participants are incentivized to ignore restrictions on their participation, and no centralized clinical trial registry prevents dual enrollment. Little is currently known about how healthy volunteers participate in studies over time, hampering the development of policies to protect this group. We detail a methodology developed as part of a longitudinal study to track in real-time healthy volunteers' Phase I participation. Illustrating these data through three case studies, we document how healthy volunteers use strategies, such as qualifying for studies at more than one clinic and traveling significant distances, to maximize their participation. Our findings suggest that "clinical trial diaries" can generate critical information about serial research participation and point to ethical issues unique to healthy volunteers' involvement in Phase I clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.