ArticleeLife2015
Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- The utilization of small non-mammals in traumatic brain injury research: A systematic review.CNS neuroscience & therapeutics · 2021Pooled it
- Genetic variation in innate immune gene expression influences mortality after traumatic brain injury in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Article
- Predicting the functional impact of single nucleotide variants in Drosophila melanogaster with FlyCADD.Genetics · 2026Article
- Exploring the versatility ofFly · 2025Review
- Two-phase model of ageing in mice for improved identification of age-related and late life metabolic decline.BMC biology · 2025Article
- Quantitative genetics of trauma induced mortality inbioRxiv : the preprint server for biology · 2025Article
- Genetic Differences Modify Anesthetic Preconditioning of Traumatic Brain Injury in Drosophila.Journal of neurotrauma · 2025Article
- Article
- The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation.Investigative ophthalmology & visual science · 2025Article
- A genome-wide association study implicates the olfactory system inbioRxiv : the preprint server for biology · 2025Article
- Traumatic brain injury induces DNA damage in Drosophila.microPublication biology · 2025Article
- Traumatic brain injury reprograms lipid droplet metabolism shaped by aging and diet in Drosophila brain.PloS one · 2025Article
- Article
- A Pvr-AP-1-Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury.eLife · 2024Article
- The Influence of Cannabinoids onCannabis and cannabinoid research · 2024Article
- TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity inInternational journal of molecular sciences · 2024Article
- Mild traumatic brain injury in Drosophila melanogaster alters reactive oxygen and nitrogen species in a sex-dependent manner.Experimental neurology · 2024Article
- Ageing as a two-phase process: theoretical framework.Frontiers in aging · 2024Article
- Dietary restriction mitigates phenotypes induced by traumatic brain injury (TBI) in femalemicroPublication biology · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Unfavorable TBI outcomes result from primary mechanical injuries to the brain and ensuing secondary non-mechanical injuries that are not limited to the brain. Our genome-wide association study of Drosophila melanogaster revealed that the probability of death following TBI is associated with single nucleotide polymorphisms in genes involved in tissue barrier function and glucose homeostasis. We found that TBI causes intestinal and blood-brain barrier dysfunction and that intestinal barrier dysfunction is highly correlated with the probability of death. Furthermore, we found that ingestion of glucose after a primary injury increases the probability of death through a secondary injury mechanism that exacerbates intestinal barrier dysfunction. Our results indicate that natural variation in the probability of death following TBI is due in part to genetic differences that affect intestinal barrier dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.