ArticleTransplantation2015
Primary Cardiac Allograft Dysfunction-Validation of a Clinical Definition.
Article in Transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- A Comparison of postoperative hemodynamic trajectories in donation after brain death versus circulatory death heart transplantation.JHLT open · 2026Article
- Recipient plasma metabolomics as a predictor of heart transplant severe primary graft dysfunction.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Beating heart transplantation: A single center's initial experience and propensity-matched analysis against national registry data.JHLT open · 2026Article
- Incidence, predictors and outcomes following primary graft dysfunction after cardiac transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Contemporary strategies for donor heart preservation in heart transplantation.Frontiers in transplantation · 2026Review
- Primary graft dysfunction in heart transplantation: the challenge to survival.Journal of cardiothoracic surgery · 2024Review
- Risk prediction models of primary graft dysfunction in cardiac transplant patients: a need to improve?Frontiers in cardiovascular medicine · 2024Article
- Review
- A machine learning model for prediction of 30-day primary graft failure after heart transplantation.Heliyon · 2023Article
- Post-transplant inotrope score is associated with clinical outcomes after adult heart transplantation.Clinical transplantation · 2021Article
- Amiodarone Use Prior to Cardiac Transplant Impacts Early Post-Transplant Survival.Cardiovascular drugs and therapy · 2021Article
- Stimulation of soluble guanylate cyclase improves donor organ function in rat heart transplantation.Scientific reports · 2020Article
- Primary graft dysfunction after heart transplantation: a thorn amongst the roses.Heart failure reviews · 2019Review
- Associated Clinical and Laboratory Markers of Donor on Allograft Function After Heart Transplant.Brazilian journal of cardiovascular surgery · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHeart transplantation is an established treatment for advanced heart failure. Primary allograft dysfunction (PGD) is reported in up to 40% of transplants and is associated with a poor outcome.
methodsAs part of Heart Evaluation and Retrieval for Transplantation study, an investigation of the assessment of donor hearts for transplantation, we proposed a clinical definition for cardiac PGD comprising severely impaired systolic function affecting one or both ventricles accompanied by hypotension, low cardiac output, and high filling pressures occurring in the first 72 hours (in the absence of hyper acute rejection and technical surgical factors, such as cardiac tamponade). Here, we examine the prospective application of this definition to 290 heart transplants. We compared the clinical outcome of PGD and non-PGD cases.
resultsNinety-four of 290 transplants developed PGD (32.4%). Inotrope use (score) was higher in the PGD group at 24, 48, and 72 hours after transplantation (P < 0.01). In the PGD group, there was a greater requirement for, intra-aortic balloon pump (50% vs 15%, P < 0.01), mechanical support (27% vs 0%, P < 0.01), and renal replacement therapy (61% vs 26%, P < 0.01). Intensive care stay was longer for recipients with PGD (median 14 vs 5 days, P < 0.01) and early mortality was higher (37% vs 4% at 30 days, 42% vs 8% at 1 year, P < 0.01).
conclusionsIn conclusion, our definition of PGD could be applied in a national multicenter study, and the cases it defined had more frequent complications and higher mortality.
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