Evidence map›Paper›PMID 25742370›Full record

Trial reportJournal of neurologic physical therapy : JNPT2015

Exercise and medication effects on persons with Parkinson disease across the domains of disability: a randomized clinical trial.

Leland E Dibble, K Bo Foreman, Odessa Addison, Robin L Marcus, Paul C LaStayo

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurologic physical therapy : JNPT, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 9 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 9 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  19. Exercise and Parkinson's Disease.Advances in experimental medicine and biology · 2020
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Leland E DibbleDepartment of Physical Therapy (L.E.D., K.B.F., R.L.M., P.C.L.), University of Utah, Salt Lake City; and Department of Medicine (O.A.), Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, and Veterans Affairs Geriatric Research, Education and Clinical Center and Research Development Service, Baltimore.
K Bo Foreman
Odessa Addison
Robin L Marcus
Paul C LaStayo
University of Baltimore · USUniversity of Maryland, Baltimore · US

Funding

High Force Resistance Training and Dopamine Replacement Effects on Hypokinesia inR15HD056478 · NICHD · UNIVERSITY OF UTAH · PI DIBBLE, LELAND ERIC · 2007 to 2007
$225k
NICHD NIH HHS 1-R15 HD056478-01NICHD NIH HHS R15 HD056478
6 · The paper itself

Abstract

background and purposeHypokinesia and bradykinesia as movement deficits of Parkinson disease are thought to be mediated by both basal ganglia dysfunction and a loss of muscle mass and strength commensurate with aging and decreased levels of physical activity. For these reasons, we sought to utilize resistance training as a means to increase muscle force and minimize hypokinesia and bradykinesia in persons with Parkinson disease and examine the effects of exercise and medication on Body Structure and Function (muscle force production and muscle cross-sectional area), Activity (mobility), and Participation (Health Status) outcomes.

methodsForty-two participants were enrolled in a 12-week randomized clinical trial that compared 2 active exercise interventions: a standard care control group (Active Control) and an experimental group that underwent Resistance Exercise via Negative Eccentric Work (RENEW).

resultsParticipants in both groups improved in muscle force production and mobility as a result of exercise and medication (P < 0.02). There were no significant interaction or between-group differences and no significant changes in muscle cross-sectional area or health status were observed. Effect sizes for exercise and medication combined exceeded the effect sizes of either intervention in isolation. DISCUSSION AND

conclusionsTaken together, these results point to the complementary effects of exercise and medication on the Body Structure and Function and Activity outcomes but little effect on Participation outcomes.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A92).

Indexed as

AgedFemaleHumansHypokinesiaMaleMiddle AgedParkinson DiseaseResistance TrainingSeverity of Illness IndexTreatment Outcome

Identifiers

PMID25742370
PMCPMC4366306
OpenAlexW2069014105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.