Evidence map›Paper›PMID 25742299›Full record

ArticleALTEX2015

The human toxome project.

Mounir Bouhifd, Melvin E Andersen, Christina Baghdikian, Kim Boekelheide, Kevin M Crofton, Albert J Fornace, Andre Kleensang, Henghong Li, Carolina Livi, Alexandra Maertens and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ALTEX, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Article
  6. Review
  7. Article
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  9. Review
  10. Article
  11. Article
  12. Article
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  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Animal-Free Chemical Safety Assessment.Frontiers in pharmacology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mounir BouhifdJohns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Melvin E AndersenThe Hamner Institute, Research Triangle Park, NC, USA.
Christina BaghdikianASPPH Fellow, National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, USA.
Kim BoekelheideBrown University, Pathology & Laboratory Medicine, Providence, RI, USA.
Kevin M CroftonUS EPA, National Center for Computational Toxicology, Research Triangle Park, NC, USA.
Albert J FornaceGeorgetown University Medical Center, Washington, DC, USA.
Andre KleensangJohns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Henghong LiGeorgetown University Medical Center, Washington, DC, USA.
Carolina LiviAgilent Inc., Santa Clara, CA, USA.
Alexandra MaertensJohns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Patrick D McMullenThe Hamner Institute, Research Triangle Park, NC, USA.
Michael RosenbergAgilent Inc., Santa Clara, CA, USA.
Russell ThomasUS EPA, National Center for Computational Toxicology, Research Triangle Park, NC, USA.
Marguerite VantangoliBrown University, Pathology & Laboratory Medicine, Providence, RI, USA.
James D YagerJohns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD, USA.
Liang ZhaoJohns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Thomas HartungJohns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.

Funding

TRAINING IN ENVIRONMENTAL PATHOLOGYT32ES007272 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 1992 to 2021
$7.5M
Mapping the Human Toxome by Systems ToxicologyR01ES020750 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HARTUNG, THOMAS · 2011 to 2015
$6.0M
FDA HHS U01 FD 004230FDA HHS U01 FD004230NIEHS NIH HHS R01 ES 020750NIEHS NIH HHS R01 ES020750NIEHS NIH HHS T32 ES007272
6 · The paper itself

Abstract

The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectroscopy-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies.

Indexed as

AnimalsAnimal Testing AlternativesDatabases, FactualEndocrine DisruptorsHumansMetabolomicsMiceToxicity TestsToxicologyTranscriptomeEndocrine Disruptorsalternative methodsmetabolomicsregulatory toxicologysafety sciencestranscriptomics

Identifiers

PMID25742299
PMCPMC4778566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.