ArticleMemorias do Instituto Oswaldo Cruz2015
Experimental infection with the Toxoplasma gondii ME-49 strain in the Brazilian BR-1 mini pig is a suitable animal model for human toxoplasmosis.
Article in Memorias do Instituto Oswaldo Cruz, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Chronic Toxoplasma gondii infection and its influence on semen analysis in rats: controlled experimental animal study.Scientific reports · 2026Article
- Effects of diet and ovariectomy onBrain communications · 2025Article
- Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages.Nature communications · 2024Article
- Therapeutic potential ofBrain communications · 2024Article
- Establishment of a murine model of congenital toxoplasmosis and validation of a qPCR assay to assess the parasite load in maternal and fetal tissues.Frontiers in microbiology · 2023Article
- Unifying Virulence Evaluation inFrontiers in cellular and infection microbiology · 2022Review
- Viability ofVeterinary world · 2022Article
- From Entry to Early Dissemination-Frontiers in cellular and infection microbiology · 2019Review
- Serum Metabolic Profiling of Oocyst-InducedFrontiers in microbiology · 2017Article
- Dextran sulfate inhibits acute Toxoplama gondii infection in pigs.Parasites & vectors · 2016Article
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxoplasma gondii causes toxoplasmosis, a worldwide disease. Experimentation with pigs is necessary for the development of new therapeutic approaches to human diseases. BR-1 mini pigs were intramuscularly infected with T. gondii with tachyzoites (RH strain) or orally infected with cysts (ME-49 strain). Haematology and serum biochemistry were analysed and buffy coat cells were inoculated in mice to determine tachyzoite circulation. No alterations were observed in erythrocyte and platelet values; however, band neutrophils increased seven days after infection with ME-49. Serology of the mice inoculated with pig blood leucocytes revealed circulating ME-49 or RH strain tachyzoites in the pigs' peripheral blood at two and seven or nine days post-infection. The tachyzoites were also directly observed in blood smears from the infected pigs outside and inside leucocytes for longer periods. Alanine-aminotransferase was high at days 21 and 32 in the RH infected pigs. After 90 days, the pigs were euthanised and their tissue samples were processed and inoculated into mice. The mice serology revealed the presence of parasites in the hearts, ileums and mesenteric lymph nodes of the pigs. Additionally, cysts in the mice were only observed after pig heart tissue inoculation. The infected pigs presented similar human outcomes with relatively low pathogenicity and the BR-1 mini pig model infected with ME-49 is suitable to monitor experimental toxoplasmosis.
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