ArticleMemorias do Instituto Oswaldo Cruz2015
Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.
Article in Memorias do Instituto Oswaldo Cruz, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease-Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities.Chemistry & biodiversity · 2025Article
- A review on fungal endophytes of the family Fabaceae, their metabolic diversity and biological applications.Heliyon · 2025Review
- Evaluation of Beauvericin's activity and mode of action against all life stages ofFrontiers in cellular and infection microbiology · 2025Article
- Review
- Review
- Cacti as low-cost substrates to produce L-asparaginase by endophytic fungi.World journal of microbiology & biotechnology · 2022Article
- Enzymatic and Molecular Characterization of Anti-Molecules (Basel, Switzerland) · 2022Article
- Multigene Phylogeny, Beauvericin Production and Bioactive Potential ofJournal of fungi (Basel, Switzerland) · 2022Article
- Physicochemical, Pharmacokinetic and Cytotoxicity of the Compounds Isolated from an EndophyteToxins · 2022Article
- Multi-functional bioactive secondary metabolites derived from endophytic fungi of marine algal origin.Current research in microbial sciences · 2021Article
- Bioactive Compounds from Mangrove Endophytic Fungus and Their Uses for Microorganism Control.Journal of fungi (Basel, Switzerland) · 2021Review
- Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases.Molecules (Basel, Switzerland) · 2021Review
- Anti-leishmanial and anti-trypanosomal natural products from endophytes.Parasitology research · 2021Review
- Chemical Diversity of Secondary Metabolites Produced by Brazilian Endophytic Fungi.Current microbiology · 2021Review
- Bioprospecting endophytic fungi fromMycology · 2020Review
- Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood).Memorias do Instituto Oswaldo Cruz · 2018Article
- Bioactive compounds of Aspergillus terreus-F7, an endophytic fungus from Hyptis suaveolens (L.) Poit.World journal of microbiology & biotechnology · 2017Article
- Antiangiogenic, wound healing and antioxidant activity ofMycology · 2016Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and Escherichia coli [minimal inhibitory concentration (MIC) 32-64 μg/mL]. One isolate inhibited the growth of Salmonella typhimurium (MIC 64 μg/mL) and two isolates inhibited the growth of Klebsiella oxytoca (MIC 64 μg/mL), Candida albicans and Candida tropicalis (MIC 64-128 μg/mL). Fourteen extracts at a concentration of 20 μg/mL showed antitumour activities against human breast cancer and human renal cancer cells, while two isolates showed anti-tumour activities against human melanoma cancer cells. Six extracts were able to reduce the proliferation of human peripheral blood mononuclear cells, indicating some degree of selective toxicity. Four isolates were able to inhibit Leishmania (Leishmania) amazonensis and one isolate inhibited Trypanosoma cruzi by at least 40% at 20 μg/mL. The trypanocidal extract obtained from Fusarium sp. [KF611679] culture was subjected to bioguided fractionation, which revealed beauvericin as the compound responsible for the observed toxicity of Fusarium sp. to T. cruzi. This depsipeptide showed a half maximal inhibitory concentration of 1.9 μg/mL (2.43 μM) in a T. cruzi cellular culture assay.
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