ArticleMemorias do Instituto Oswaldo Cruz2015
Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine.
Article in Memorias do Instituto Oswaldo Cruz, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Harnessing Phytonanotechnology to Tackle Neglected Parasitic Diseases: Focus on Chagas Disease and Malaria.Pharmaceutics · 2025Review
- The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review.Molecules (Basel, Switzerland) · 2023Review
- Chalcone Derivative Induces Flagellar Disruption and Autophagic Phenotype inPathogens (Basel, Switzerland) · 2023Article
- Combination With Tomatidine Improves the Potency of Posaconazole AgainstFrontiers in cellular and infection microbiology · 2021Article
- The Enhanced Expression of Cruzipain-Like Molecules in the PhytoflagellateFrontiers in cellular and infection microbiology · 2021Article
- Comparative Therapeutic Effects of Natural Compounds AgainstFrontiers in veterinary science · 2020Article
- Chemical Composition and Biological Activities ofBiomolecules · 2019Article
- Not all saponins have a greater antiprotozoal activity than their related sapogenins.FEMS microbiology letters · 2019Article
- RNA-Seq Analyses of Midgut and Fat Body Tissues Reveal the Molecular Mechanism UnderlyingFrontiers in physiology · 2019Article
- Not in your usual Top 10: protists that infect plants and algae.Molecular plant pathology · 2018Review
- Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens.Antimicrobial agents and chemotherapy · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytomonas serpens are flagellates in the family Trypanosomatidae that parasitise the tomato plant (Solanum lycopersicum L.), which results in fruits with low commercial value. The tomato glycoalkaloid tomatine and its aglycone tomatidine inhibit the growth of P. serpens in axenic cultures. Tomatine, like many other saponins, induces permeabilisation of the cell membrane and a loss of cell content, including the cytosolic enzyme pyruvate kinase. In contrast, tomatidine does not cause permeabilisation of membranes, but instead provokes morphological changes, including vacuolisation. Phytomonas treated with tomatidine show an increased accumulation of labelled neutral lipids (BODYPY-palmitic), a notable decrease in the amount of C24-alkylated sterols and an increase in zymosterol content. These results are consistent with the inhibition of 24-sterol methyltransferase (SMT), which is an important enzyme that is responsible for the methylation of sterols at the 24 position. We propose that the main target of tomatidine is the sterols biosynthetic pathway, specifically, inhibition of the 24-SMT. Altogether, the results obtained in the present paper suggest a more general effect of alkaloids in trypanosomatids, which opens potential therapeutic possibilities for the treatment of the diseases caused by these pathogens.
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