Evidence map›Paper›PMID 25742187›Full record

ArticleChest2015

Understanding the Concept of Health Care-Associated Pneumonia in Lung Transplant Recipients.

Federico Palacio, Luis F Reyes, Deborah J Levine, Juan F Sanchez, Luis F Angel, Juan F Fernandez, Stephanie M Levine, Jordi Rello, Ali Abedi, Marcos I Restrepo

Abstract read
In one paragraph

Article in Chest, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Pneumonia after Solid Organ Transplantation.Seminars in respiratory and critical care medicine · 2026
    Review
  3. Review
  4. Burden and Management of Multi-Drug Resistant Organism Infections in Solid Organ Transplant Recipients Across the World: A Narrative Review.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Federico PalacioSouth Texas Veterans Health Care System, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX.
Luis F ReyesUniversity of Texas Health Science Center at San Antonio, San Antonio, TX; Universidad de La Sabana, Bogota, Colombia.
Deborah J LevineSouth Texas Veterans Health Care System, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX.
Juan F SanchezScott and White Health Care System, Temple, TX.
Luis F AngelUniversity of Texas Health Science Center at San Antonio, San Antonio, TX.
Juan F FernandezUniversity of Texas Health Science Center at San Antonio, San Antonio, TX.
Stephanie M LevineSouth Texas Veterans Health Care System, San Antonio, TX.
Jordi RelloHospital Universitari Vall d'Hebron, Vall d'Hebron Institute of Research, CIBERES, Universitat Autonoma de Barcelona, Barcelona, Spain).
Ali AbediUniversity of Texas Health Science Center at San Antonio, San Antonio, TX.
Marcos I RestrepoSouth Texas Veterans Health Care System, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX. Electronic address: restrepom@uthscsa.edu.

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthKL2TR001118 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, DOUGHERTY, DONALD M · 2013 to 2017
$3.4M
Effect of macrolides as immunomodulators in patients with sepsis and pneumoniaK23HL096054 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RESTREPO, MARCOS I. · 2010 to 2014
$689k
NCATS NIH HHS KL2 TR001118NCATS NIH HHS UL1 TR001120NHLBI NIH HHS K23 HL096054NHLBI NIH HHS K23HL096054
6 · The paper itself

Abstract

backgroundLimited data are available regarding the etiologic impact of health care-associated pneumonia (HCAP) in lung transplant recipients. Therefore, our aim was to evaluate the microbiologic differences between HCAP and hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) in lung transplant recipients with a radiographically confirmed diagnosis of pneumonia.

methodsWe performed a retrospective cohort study of lung transplant recipients with pneumonia at one transplant center over a 7-year period. Eligible patients included lung transplant recipients who developed a first episode of radiographically confirmed pneumonia ≥ 48 h following transplantation. HCAP, HAP, and VAP were classified according to the American Thoracic Society/Infectious Diseases Society of America 2005 guidelines. χ² and Student t tests were used to compare categorical and continuous variables, respectively.

resultsSixty-eight lung transplant recipients developed at least one episode of pneumonia. HCAP (n = 42; 62%) was most common, followed by HAP/VAP (n = 26; 38%) stratified in HAP (n = 20; 77%) and VAP (n = 6; 23%). Pseudomonas aeruginosa was the predominantly isolated organism (n = 22; 32%), whereas invasive aspergillosis was uncommon (< 10%). Multiple-drug resistant (MDR) pathogens were less frequently isolated in patients with HCAP compared with HAP/VAP (5% vs 27%; P = .009). Opportunistic pathogens were less frequently identified in lung transplant recipients with HCAP than in those with HAP/VAP (7% vs 27%; P = .02). Lung transplant recipients with HCAP had a similar mortality at 90 days (n = 9 [21%] vs n = 4 [15%]; P = .3) compared with patients with HAP/VAP.

conclusionsHCAP was the most frequent infection in lung transplant recipients. MDR pathogens and opportunistic pathogens were more frequently isolated in HAP/VAP. There were no differences in 30- and 90-day mortality between lung transplant recipients with HCAP and those with HAP/VAP.

Indexed as

Drug Resistance, Multiple, BacterialLung TransplantationAnti-Bacterial AgentsCohort StudiesCross InfectionFemaleGraft RejectionHumansImmunosuppressive AgentsMaleMiddle AgedPneumoniaPneumonia, Ventilator-AssociatedRetrospective StudiesAnti-Bacterial AgentsImmunosuppressive Agents

Identifiers

PMID25742187
PMCPMC4524330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.