Evidence map›Paper›PMID 25742006›Full record

ArticlePloS one2015

Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis.

Amanda L McGuire, Sophia C Bennett, Sally M Lansley, Natalia D Popowicz, Julius F Varano della Vergiliana, Daniel Wong, Y C Gary Lee, Aron Chakera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Amanda L McGuireTranslational Renal Research Group, Harry Perkins Institute of Medical Research, Perth, Australia; University of Western Australia, School of Medicine and Pharmacology, Perth, Australia.
Sophia C BennettTranslational Renal Research Group, Harry Perkins Institute of Medical Research, Perth, Australia; University of Western Australia, School of Medicine and Pharmacology, Perth, Australia.
Sally M LansleyPleural Disease Unit, Lung Institute of Western Australia, Centre for Asthma, Allergy Respiratory Research, School of Medicine and Pharmacology, Perth, Australia.
Natalia D PopowiczPleural Disease Unit, Lung Institute of Western Australia, Centre for Asthma, Allergy Respiratory Research, School of Medicine and Pharmacology, Perth, Australia.
Julius F Varano della VergilianaPleural Disease Unit, Lung Institute of Western Australia, Centre for Asthma, Allergy Respiratory Research, School of Medicine and Pharmacology, Perth, Australia.
Daniel WongDepartment of Anatomical Pathology, PathWest Laboratory Medicine WA, QEII Medical Centre, Perth, Australia.
Y C Gary LeePleural Disease Unit, Lung Institute of Western Australia, Centre for Asthma, Allergy Respiratory Research, School of Medicine and Pharmacology, Perth, Australia; Respiratory Department, Sir Charles Gairdner Hospital, Perth, Australia.
Aron ChakeraTranslational Renal Research Group, Harry Perkins Institute of Medical Research, Perth, Australia; University of Western Australia, School of Medicine and Pharmacology, Perth, Australia; Renal Department, Sir Charles Gairdner Hospital, Perth, Australia.
Institute for Respiratory Health · AUHarry Perkins Institute of Medical Research · AUPathwest Laboratory Medicine · AUSir Charles Gairdner Hospital · AUUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritoneal cavity, which may reduce the effectiveness of antimicrobial agents and predispose to recurrence or relapse of infection. Strategies to enhance responses to antimicrobial agents therefore have the potential to improve patient outcomes. This study presents pre-clinical data describing the compatibility of tPA and DNase in combination with antimicrobial agents used for the treatment of PD peritonitis. tPA and DNase were stable in standard dialysate solution and in the presence of antimicrobial agents, and were safe when given intraperitoneally in a mouse model with no evidence of local or systemic toxicity. Adjunctive tPA and DNase may have a role in the management of patients presenting with PD peritonitis.

Indexed as

Peritoneal DialysisAnimalsAnti-Infective AgentsDeoxyribonucleasesFemaleMicePeritonitisTissue Plasminogen ActivatorAnti-Infective AgentsDeoxyribonucleasesTissue Plasminogen Activator

Identifiers

PMID25742006
PMCPMC4351066
OpenAlexW2151111626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.