ArticleGenetics in medicine : official journal of the American College of Medical Genetics2015
Development of clinical decision support alerts for pharmacogenomic incidental findings from exome sequencing.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- Identification of Drugs Acting as Perpetrators in Common Drug Interactions in a Cohort of Geriatric Patients from Southern Italy and Analysis of the Gene Polymorphisms That Affect Their Interacting Potential.Geriatrics (Basel, Switzerland) · 2023Article
- Studying the impact of translational genomic research: Lessons from eMERGE.American journal of human genetics · 2023Review
- Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.Annual review of genomics and human genetics · 2022Review
- PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics.Journal of clinical medicine · 2021Review
- Revisiting Secondary Information Related to Pharmacogenetic Testing.Frontiers in genetics · 2021Article
- An ancillary genomics system to support the return of pharmacogenomic results.Journal of the American Medical Informatics Association : JAMIA · 2019Article
- Patient Decisions to Receive Secondary Pharmacogenomic Findings and Development of a Multidisciplinary Practice Model to Integrate Results Into Patient Care.Clinical and translational science · 2018Article
- Integrating clinical decision support systems for pharmacogenomic testing into clinical routine - a scoping review of designs of user-system interactions in recent system development.BMC medical informatics and decision making · 2017Article
- Pharmacogenomic incidental findings in 308 families: The NIH Undiagnosed Diseases Program experience.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Physician perspectives of CYP2C19 and clopidogrel drug-gene interaction active clinical decision support alerts.International journal of medical informatics · 2016Article
- Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene,NPJ genomic medicine · 2016Article
- Modeling the costs of clinical decision support for genomic precision medicine.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2016Article
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7 authors.
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Abstract
purposeElectronic health records (EHRs) and their associated decision support tools are potentially important means of disseminating a patient's pharmacogenomic profile to his or her health-care providers. We sought to create a proof-of-concept decision support alert system generated from pharmacogenomic incidental findings from exome sequencing.
methodsA pipeline for alerts from exome sequencing tests was created for patients in the New EXome Technology in (NEXT) Medicine study at the University of Washington. Decision support rules using discrete, machine-readable incidental finding results were programmed into a commercial EHR rules engine. An evaluation plan to monitor the alerts in real medical interactions was established.
resultsAlerts were created for 48 actionable pharmacogenomic variants in 11 genes and were launched on 24 September 2014 for University of Washington inpatient care. Of the 94 participants enrolled in the NEXT Medicine study, 49 had one or more pharmacogenomic variants identified for return.
conclusionReflections on the process reveal that while incidental findings can be used to generate decision support alerts, substantial resources are required to ensure that each alert is consistent with rapidly evolving pharmacogenomic literature and is customized to fit in the clinical workflow unique to each incidental finding.
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