ReviewNPJ primary care respiratory medicine2015
Why aren't we doing better in asthma: time for personalised medicine?
Review in NPJ primary care respiratory medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of methodology used in the development of prediction models for future asthma exacerbation.BMC medical research methodology · 2020Pooled it
- A feasibility trial of a digital mindfulness-based intervention to improve asthma-related quality of life for primary care patients with asthma.Journal of behavioral medicine · 2022Trial
- Findings from a pilot Randomised trial of an Asthma Internet Self-management Intervention (RAISIN).BMJ open · 2016Trial
- Patient experiences of their current asthma care and their views toward providing support for patients with asthma in community pharmacy: A Qualitative study.Exploratory research in clinical and social pharmacy · 2024Article
- An Accelerometer-Based Wearable Patch for Robust Respiratory Rate and Wheeze Detection Using Deep Learning.Biosensors · 2024Article
- Qualitative study on perceptions of use of Fractional Exhaled Nitric Oxide (FeNO) in asthma reviews.NPJ primary care respiratory medicine · 2022Article
- Essential Role of Pharmacists in Asthma Care and Management.Journal of pharmacy practice · 2021Review
- Patient-Generated Health Data in Pediatric Asthma: Exploratory Study of Providers' Information Needs.JMIR pediatrics and parenting · 2021Article
- Future Trends in Nebulized Therapies for Pulmonary Disease.Journal of personalized medicine · 2020Review
- Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma.Frontiers in medicine · 2020Article
- A multicenter, open-label, noninterventional study to evaluate the impact on clinical effects, user-friendliness and patients' acceptance of AirFluSal Forspiro in the treatment of asthma under real-life conditions (ASSURE).Pragmatic and observational research · 2019Article
- Interventions on Adherence to Treatment in Children With Severe Asthma: A Systematic Review.Frontiers in pediatrics · 2018Article
- Living with asthma and chronic obstructive airways disease: Using technology to support self-management - An overview.Chronic respiratory disease · 2017Review
- Self-management research of asthma and good drug use (SMARAGD study): a pilot trial.International journal of clinical pharmacy · 2017Article
- Adaptation of a difficult-to-manage asthma programme for implementation in the Dutch context: a modified e-Delphi.NPJ primary care respiratory medicine · 2017Article
- Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation.Immune network · 2016Article
- The use of inhaled corticosteroids in pediatric asthma: update.The World Allergy Organization journal · 2016Review
- Towards tailored and targeted adherence assessment to optimise asthma management.NPJ primary care respiratory medicine · 2015Article
- GEMA 5.3. Spanish Guideline on the Management of Asthma.Open respiratory archivesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After decades of improvement, asthma outcomes have stalled. Mortality, hospitalisations, exacerbations and symptom control remain sub-optimal. In controlled trials, most patients gain high levels of control, but in 'real-life' routine clinical practice most patients do not. Avoidable factors are found in most asthma deaths and hospital admissions. This perspective paper considers and contextualises the factors underlying poor asthma outcomes, and it suggests approaches that could improve the situation. Factors discussed include severe, therapy-resistant disease and the role of new and upcoming pharmacological therapies in improving outcomes. These are likely to be beneficial when targeted on patients with severe disease and discrete phenotypic characteristics, identified through biomarkers. However, for the majority of patients treated in the community, they are unlikely to be used widely, and better use of current therapy classes will be more important. Non-adherence with regular inhaled corticosteroid treatment and over-use of rescue bronchodilators are common, and many patients have poor inhaler technique. Self-management is frequently poor, particularly in those with psychosocial disadvantages and co-morbidities. Communication between clinicians and patients is sometimes poor, with failure to detect avoidable poor control and non-adherence, and failure to provide the necessary information and education to support efficient self-management. Strategies for improving monitoring and clinician-patient interactions to allow personalised treatment are considered. These strategies have the potential to allow individual patient needs to be recognised and efficient targeting of the variety of effective pharmacological and non-pharmacological interventions that we possess, which has the potential to improve both individual and population outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.