Evidence map›Paper›PMID 25741731›Full record

ArticleNeuron2015

Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations.

Daniel von Bornstädt, Thijs Houben, Jessica L Seidel, Yi Zheng, Ergin Dilekoz, Tao Qin, Nora Sandow, Sreekanth Kura, Katharina Eikermann-Haerter, Matthias Endres and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 2 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 2 syntheses or guidelines pooled it, 199 citations in OpenAlex.

  1. Pooled it
  2. Systematic review of the pharmacological agents that have been tested against spreading depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Pooled it
  3. Trial
  4. Trial
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  6. Article
  7. Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  8. Article
  9. Article
  10. Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  12. Review
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  16. Observational
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 4 countries.

Daniel von BornstädtNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA; Department of Neurology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Center for Stroke Research, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Thijs HoubenNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA; Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, the Netherlands.
Jessica L SeidelNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Yi ZhengNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Ergin DilekozNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA; Department of Pharmacology, Gazi University Faculty of Medicine, Besevler Campus, 06560 Ankara, Turkey.
Tao QinNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Nora SandowDepartment of Neurosurgery, Charité - Universitätsmedizin Augustenburger Platz 1, 13353 Berlin, Germany; Center for Stroke Research, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Sreekanth KuraOptics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Katharina Eikermann-HaerterNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Matthias EndresDepartment of Neurology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Center for Stroke Research, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; German Centre for Cardiovascular Research (DZHK), Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
David A BoasOptics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Michael A MoskowitzNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Eng H LoNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Jens P DreierDepartment of Neurology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Center for Stroke Research, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Johannes WoitzikDepartment of Neurosurgery, Charité - Universitätsmedizin Augustenburger Platz 1, 13353 Berlin, Germany; Center for Stroke Research, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Sava SakadžićOptics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA.
Cenk AyataNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13(th) Street, 6408, Charlestown, MA 02129, USA; Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: cayata@partners.org.
Harvard University · USMassachusetts General Hospital · USCharité - Universitätsmedizin Berlin · DEGerman Centre for Cardiovascular Research · DE

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine ModelsR01NS061505 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK · 2008 to 2012
$1.8M
NINDS NIH HHS NS055104NINDS NIH HHS NS061505NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS061505
6 · The paper itself

Abstract

Peri-infarct depolarizations (PIDs) are seemingly spontaneous spreading depression-like waves that negatively impact tissue outcome in both experimental and human stroke. Factors triggering PIDs are unknown. Here, we show that somatosensory activation of peri-infarct cortex triggers PIDs when the activated cortex is within a critical range of ischemia. We show that the mechanism involves increased oxygen utilization within the activated cortex, worsening the supply-demand mismatch. We support the concept by clinical data showing that mismatch predisposes stroke patients to PIDs as well. Conversely, transient worsening of mismatch by episodic hypoxemia or hypotension also reproducibly triggers PIDs. Therefore, PIDs are triggered upon supply-demand mismatch transients in metastable peri-infarct hot zones due to increased demand or reduced supply. Based on the data, we propose that minimizing sensory stimulation and hypoxic or hypotensive transients in stroke and brain injury would reduce PID incidence and their adverse impact on outcome. VIDEO ABSTRACT:

Indexed as

AdultAgedAnimalsCerebral InfarctionCortical Spreading DepressionFemaleHumansInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMiddle AgedSomatosensory Cortex

Identifiers

PMID25741731
PMCPMC4351476
OpenAlexW1975980016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.