ArticleNeuron2015
ON and OFF unipolar brush cells transform multisensory inputs to the auditory system.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells.Cell research · 2026Article
- Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.Nature communications · 2025Article
- Balance Performance in Aged Mice is Dependent on Unipolar Brush Cells.Cerebellum (London, England) · 2024Article
- Realistic mossy fiber input patterns to unipolar brush cells evoke a continuum of temporal responses comprised of components mediated by different glutamate receptors.bioRxiv : the preprint server for biology · 2024Article
- Balance performance in aged mice is dependent on unipolar brush cells.bioRxiv : the preprint server for biology · 2024Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.bioRxiv : the preprint server for biology · 2024Article
- Review
- Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1.Neuron · 2024Article
- A system of feed-forward cerebellar circuits that extend and diversify sensory signaling.eLife · 2024Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- A Continuum of Response Properties across the Population of Unipolar Brush Cells in the Dorsal Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation.Biomedicines · 2023Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Descending Axonal Projections from the Inferior Colliculus Target Nearly All Excitatory and Inhibitory Cell Types of the Dorsal Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.Nature communications · 2021Article
- Article
- Regulating synchronous oscillations of cerebellar granule cells by different types of inhibition.PLoS computational biology · 2021Article
- Article
- Approaches to Understanding Multisensory Dysfunction in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Unipolar brush cells (UBCs) of the dorsal cochlear nucleus (DCN) and vestibular cerebellar cortex receive glutamatergic mossy fiber input on an elaborate brush-like dendrite. Two subtypes of UBC have been established based on immunohistochemical markers and physiological profiles, but the relation of these subtypes to the response to mossy fiber input is not clear. We examined the synaptic physiology of auditory UBCs in mouse brain slices, identifying two response profiles, and correlated each with a specific UBC subtype. One subtype had a striking biphasic excitatory response mediated by AMPAR and mGluR1α. The second was mGluR1α negative and was dominated by a strongly inhibitory outward K(+) current. These two subtypes upregulated or downregulated spontaneous firing, respectively. By analogy to the retina, we propose that UBCs comprise ON and OFF cells with respect to their response to glutamatergic input and may therefore provide distinct parallel processing of multisensory input to their targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.