ArticlePloS one2015
Evidences of basal lactate production in the main white adipose tissue sites of rats. Effects of sex and a cafeteria diet.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
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- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Investigating the Chemical Composition ofFoods (Basel, Switzerland) · 2023Article
- Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice.American journal of physiology. Endocrinology and metabolism · 2022Article
- Interplay of Obesity, Ethanol, and Contaminant Mixture on Clinical Profiles of Cardiovascular and Metabolic Diseases: Evidence from an Animal Study.Cardiovascular toxicology · 2022Article
- Early unhealthy eating habits underlie morpho-functional changes in the liver and adipose tissue in male rats.Histochemistry and cell biology · 2022Article
- Estrogens and the regulation of glucose metabolism.World journal of diabetes · 2021Review
- Identification of a novel association for the WWOX/HIF1A axis with gestational diabetes mellitus (GDM).PeerJ · 2021Article
- Lactate Metabolism in Breast Cancer Microenvironment: Contribution Focused on Associated Adipose Tissue and Obesity.International journal of molecular sciences · 2020Article
- Dietary Energy Partition: The Central Role of Glucose.International journal of molecular sciences · 2020Review
- Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease.Metabolites · 2020Review
- Higher lactate production from glucose in cultured adipose nucleated stromal cells than for rat adipocytes.Adipocyte · 2019Article
- Insulin Controls Triacylglycerol Synthesis through Control of Glycerol Metabolism and Despite Increased Lipogenesis.Nutrients · 2019Article
- 3,5-Diiodo-L-Thyronine Exerts Metabolically Favorable Effects on Visceral Adipose Tissue of Rats Receiving a High-Fat Diet.Nutrients · 2019Article
- Article
- Use ofAdipocyte · 2018Article
- Glycerol is synthesized and secreted by adipocytes to dispose of excess glucose, via glycerogenesis and increased acyl-glycerol turnover.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Female and male adult Wistar rats were fed standard chow or a simplified cafeteria diet for one month. Then, the rats were killed and the white adipose tissue (WAT) in four sites: perigonadal, retroperitoneal, mesenteric and subcutaneous (inguinal) were sampled and frozen. The complete WAT weight in each site was measured. Gene expression analysis of key lipid and glucose metabolism enzymes were analyzed, as well as tissue and plasma lactate and the activity of lactate dehydrogenase. Lactate gradients between WAT and plasma were estimated. The influence of sex and diet (and indirectly WAT mass) on lactate levels and their relationships with lactate dehydrogenase activity and gene expressions were also measured. A main conclusion is the high production of lactate by WAT, practically irrespective of site, diet or sex. Lactate production is a direct correlate of lactate dehydrogenase activity in the tissue. Furthermore, lactate dehydrogenase activity is again directly correlated with the expression of the genes Ldha and Ldhb for this enzyme. In sum, the ability to produce lactate by WAT is not directly dependent of WAT metabolic state. We postulate that, in WAT, a main function of the lactate dehydrogenase path may be that of converting excess available glucose to 3C fragments, as a way to limit tissue self-utilization as substrate, to help control glycaemia and/or providing short chain substrates for use as energy source elsewhere. More information must be gathered before a conclusive role of WAT in the control of glycaemia, and the full existence of a renewed glucose-lactate-fatty acid cycle is definitely established.
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