ArticleJournal of biomedical optics2015
Study of tissue oxygen supply rate in a macroscopic photodynamic therapy singlet oxygen model.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Modeling of Singlet Oxygen Generation and Thermal Effects During Laser-Tissue Interaction.Materials (Basel, Switzerland) · 2025Article
- From reactive oxygen to cancer cell death: the science behind photodynamic therapy.Lasers in medical science · 2025Review
- Bidirectional Endothelial Feedback Drives Turing-Vascular Patterning and Drug-Resistance Niches: A Hybrid PDE-Agent-Based Study.Bioengineering (Basel, Switzerland) · 2025Article
- Sensitivity Analysis in the Problem of the Impact of an External Heat Impulse on Oxygen Distribution in Biological Tissue.Materials (Basel, Switzerland) · 2025Article
- Simulating photodynamic therapy for the treatment of glioblastoma using Monte Carlo radiative transport.Journal of biomedical optics · 2024Article
- A fast numerical method for oxygen supply in tissue with complex blood vessel network.PloS one · 2021Article
- Reactive oxygen species explicit dosimetry to predict local tumor growth for Photofrin-mediated photodynamic therapy.Biomedical optics express · 2020Article
- Single cell-based fluorescence lifetime imaging of intracellular oxygenation and metabolism.Redox biology · 2020Article
- Reactive Oxygen Species Explicit Dosimetry for Photofrin-mediated Pleural Photodynamic Therapy.Photochemistry and photobiology · 2020Article
- Article
- Reactive oxygen species explicit dosimetry to predict tumor growth for benzoporphyrin derivative-mediated vascular photodynamic therapy.Journal of biomedical optics · 2020Article
- Singlet oxygen model evaluation of interstitial photodynamic therapy with 5-aminolevulinic acid for malignant brain tumor.Journal of biomedical optics · 2019Article
- Reactive Oxygen Species Explicit Dosimetry (ROSED) of a Type 1 Photosensitizer.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Quantitative modeling of the dynamics and intracellular trafficking of far-red light-activatable prodrugs: implications in stimuli-responsive drug delivery system.Journal of pharmacokinetics and pharmacodynamics · 2017Article
- A Comparison of Dose Metrics to Predict Local Tumor Control for Photofrin-mediated Photodynamic Therapy.Photochemistry and photobiology · 2017Article
- On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling.Physics in medicine and biology · 2017Review
- Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy.Journal of biomedical optics · 2017Article
- Article
- Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling.Journal of biophotonics · 2016Article
- Explicit macroscopic singlet oxygen modeling for benzoporphyrin derivative monoacid ring A (BPD)-mediated photodynamic therapy.Journal of photochemistry and photobiology. B, Biology · 2016Article
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3 authors.
Funding
Abstract
An appropriate expression for the oxygen supply rate (Γ(s)) is required for the macroscopic modeling of the complex mechanisms of photodynamic therapy (PDT). It is unrealistic to model the actual heterogeneous tumor microvascular networks coupled with the PDT processes because of the large computational requirement. In this study, a theoretical microscopic model based on uniformly distributed Krogh cylinders is used to calculate Γ(s) = g (1 - [³O₂]/[³O₂]₀) that can replace the complex modeling of blood vasculature while maintaining a reasonable resemblance to reality; g is the maximum oxygen supply rate and [³O₂]/[³O₂]₀ is the volume-average tissue oxygen concentration normalized to its value prior to PDT. The model incorporates kinetic equations of oxygen diffusion and convection within capillaries and oxygen saturation from oxyhemoglobin. Oxygen supply to the tissue is via diffusion from the uniformly distributed blood vessels. Oxygen can also diffuse along the radius and the longitudinal axis of the cylinder within tissue. The relations of Γ(s) to [³O₂]/[³O₂]₀ are examined for a biologically reasonable range of the physiological parameters for the microvasculature and several light fluence rates (ϕ). The results show a linear relationship between Γ(s) and [³O₂]/[³O₂]₀, independent of ϕ and photochemical parameters; the obtained g ranges from 0.4 to 1390 μM/s.
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