Evidence map›Paper›PMID 25741473›Full record

ArticleFrontiers in oncology2015

MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens.

Michael A Liss, Nathan S White, J Kellogg Parsons, Natalie M Schenker-Ahmed, Rebecca Rakow-Penner, Joshua M Kuperman, Hauke Bartsch, Hyung W Choi, Robert F Mattrey, William G Bradley and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03440554 (Non-contrast MR Imaging for Whole Body Cancer Detection and Characterization), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03440554 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Non-contrast MR Imaging for Whole Body Cancer Detection and Characterization

TypeinterventionalSponsorUniversity of California, San DiegoRan2016 to 2023Enrolled150ConditionsProstate CancerArmsWhole Body Non-Contrast MRI
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Comparison of synthesized and acquired high b-value diffusion-weighted MRI for detection of prostate cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI.Journal of magnetic resonance imaging : JMRI · 2017
    Review
  15. Review
  16. Article
  17. Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index with Gleason Grade in Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Michael A LissDepartment of Urology, University of California San Diego School of Medicine , San Diego, CA , USA.
Nathan S WhiteDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
J Kellogg ParsonsDepartment of Urology, University of California San Diego School of Medicine , San Diego, CA , USA.
Natalie M Schenker-AhmedDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
Rebecca Rakow-PennerDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
Joshua M KupermanDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
Hauke BartschDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
Hyung W ChoiDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
Robert F MattreyDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
William G BradleyDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
Ahmed ShabaikDepartment of Pathology, University of California San Diego School of Medicine , San Diego, CA , USA.
Jiaoti HuangDepartment of Pathology, University of California Los Angeles Geffen School of Medicine , Los Angeles, CA , USA.
Daniel J A MargolisDepartment of Radiology, University of California Los Angeles Geffen School of Medicine , Los Angeles, CA , USA.
Steven S RamanDepartment of Radiology, University of California Los Angeles Geffen School of Medicine , Los Angeles, CA , USA.
Leonard S MarksDepartment of Urology, University of California Los Angeles Geffen School of Medicine , Los Angeles, CA , USA.
Christopher J KaneDepartment of Urology, University of California San Diego School of Medicine , San Diego, CA , USA.
Robert E ReiterDepartment of Urology, University of California Los Angeles Geffen School of Medicine , Los Angeles, CA , USA.
Anders M DaleDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA ; Department of Neurosciences, University of California San Diego , La Jolla, CA , USA.
David S KarowDepartment of Radiology, University of California San Diego School of Medicine , San Diego, CA , USA.
University of California, San Diego · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe evaluate a novel magnetic resonance imaging (MRI) technique to improve detection of aggressive prostate cancer (PCa). MATERIALS AND

methodsWe performed a retrospective analysis of pre-surgical prostate MRI scans using an advanced diffusion-weighted imaging technique called restriction spectrum imaging (RSI), which can be presented as a normalized z-score statistic. Scans were acquired prior to radical prostatectomy. Prostatectomy specimens were processed using whole-mount sectioning and regions of interest (ROIs) were drawn around individual PCa tumors. Corresponding ROIs were drawn on the MRI imaging and paired with ROIs in regions with no pathology. RSI z-score and conventional apparent diffusion coefficient (ADC) values were recorded for each ROI. Paired t-test, ANOVA, and logistic regression analyses were performed.

resultsWe evaluated 28 patients with 64 ROIs (28 benign and 36 PCa). The mean difference in RSI z-score (PCa ROI-Benign ROI) was 2.17 (SE = 0.11; p < 0.001) and in ADC was 551 mm(2)/s (SE = 80 mm(2)/s; paired t-test, p < 0.001). The differences in the means among all groups (benign, primary Gleason 3, and primary Gleason 4) was significant for both RSI z-score (F 3,64 = 97.7, p < 0.001) and ADC (F 3,64 = 13.9, p < 0.001). A t-test was performed on only PCa tumor ROIs (n = 36) to determine PCa aggressiveness (Gleason 3 vs. Gleason 4) revealing that RSI z-score was still significant (p = 0.03), whereas, ADC values were no longer significant (p = 0.08). In multivariable analysis adjusting for age and race, RSI z-score was associated with PCa aggressiveness (OR 10.3, 95% CI: 1.4-78.0, p = 0.02) while ADC trended to significance (p = 0.07).

conclusionThe RSI-derived normalized cellularity index is associated with aggressive PCa as determined by pathologic Gleason scores. Further utilization of RSI techniques may serve to enhance standardized reporting systems for PCa in the future.

Indexed as

cellularityGleason scoreMRI imagingprostateprostate cancer

Identifiers

PMID25741473
PMCPMC4330697
OpenAlexW2015694955

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.