ArticleDiabetology & metabolic syndrome2015
High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population.
Article in Diabetology & metabolic syndrome, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Dose-response relationship of serum ferritin and dietary iron intake with metabolic syndrome and non-alcoholic fatty liver disease incidence: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Iron Homeostasis-Related Parameters and Hepcidin/Ferritin Ratio: Emerging Sex-Specific Predictive Markers for Metabolic Syndrome.Metabolites · 2024Article
- Serum Ferritin in Obese Dogs: Changes and Comparison with Other Analytes.Veterinary sciences · 2023Article
- The Relationship of Hyperferritinemia to Metabolism and Chronic Complications in Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- A Cross-Sectional Study of Serum Ferritin Levels in Vietnamese Adults with Metabolic Syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association of serum ferritin with metabolic syndrome in eight cities in China.Food science & nutrition · 2020Article
- Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Association of body mass index, waist circumference, and metabolic syndrome with serum cystatin C in a Chinese population.Medicine · 2017Article
- Article
- Soluble transferrin receptor levels are positively associated with insulin resistance but not with the metabolic syndrome or its individual components.The British journal of nutrition · 2016Article
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12 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated serum ferritin levels have been reported to contribute to metabolic syndrome (MetS). We examined the association of serum ferritin levels with the development of MetS in a representative sample of Chinese male adult population.
methodThe data came from the 2009-2013 Fangchenggang Area Males Health and Examination Survey (FAMHES). We combined a cross-sectional study of 2417 males and a longitudinal study of 857 males who participated in the FAMHES.
resultThe serum ferritin level of MetS was higher than that of nonMetS (median and percentiles 25-75: 447.4 (294.1-612.4) vs. 302.4 (215.0-435.8) ng/ml, p < 0.01). A positive correlation between ferritin concentrations and blood pressure (Systolic BP: R = 0.110, Diastolic BP: R = 0.158), waist circumference (R = 0.333), fasting glucose (R = 0.089), triglyceride (R = 0.315) and low high-density lipoprotein cholesterol (R = 0.130) was significant (all p < 0.001). Compared with the level of ferritin in the group with no MetS component, the group with all five MetS components had a higher ferritin level (554.7 (340.1-606.4) vs. 274.2 (198.2-384.4) ng/ml). The odd radio (OR) was higher for MetS in the highest ferritin quartile (OR = 2.29, 95% CI = 1.47-3.54) compared with the lowest ferritin quartile after adjustment for multi-factors. After 4-year follow up, 79 subjects newly diagnosed with MetS in 857 cohort male participants in 2013. Compared with the lowest ferritin quartile, the RR of the highest ferritin quartile was 2.55 (95% CI = 1.30-5.00) after multiple adjustments (p < 0.01).
conclusionOur findings confirm that the serum ferritin level is associated with the independent components of MetS, and elevated ferritin level is an independent risk factor for MetS development in the Chinese male population during the 4-year follow-up period.
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