ReviewFrontiers in microbiology2015
The importance of mass spectrometric dereplication in fungal secondary metabolite analysis.
Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 93 citations in OpenAlex.
- The endophyte secondary metabolite phenazine-1-carboxylic acid promotes tanshinone biosynthesis in Salvia miltiorrhiza callus.Journal of natural medicines · 2026Article
- Isolation of the new polyketide (-)-R-talaropinophiloic acid guided by an integrated metabolomics-dereplication approach.World journal of microbiology & biotechnology · 2026Article
- Untargeted GC-MS metabolic profiling of Eurotium chevalieri AUMC 16390 (PX498623) reveals a putative steroidal metabolite with antibacterial and anti-inflammatory potential.BMC biotechnology · 2026Article
- Refining the Study of Endophytic Fungi: Best Practices in Antibacterial Research.Current microbiology · 2026Review
- Harnessing Epigenetic Modifiers Reveals MAPK-Mediated Regulation Mechanisms in Hadal Fungi ofJournal of fungi (Basel, Switzerland) · 2025Article
- IMA fungus · 2025Review
- Harnessing multi-omics approaches to combat Karnal bunt of wheat: a review of advances and future prospects.Frontiers in genetics · 2025Review
- Article
- Comparative metabolomics study on the secondary metabolites of the red alga,RSC advances · 2024Article
- Light-Induced Changes in Secondary Metabolite Production ofJournal of fungi (Basel, Switzerland) · 2023Article
- Non-targeted Screening of Natural Products from 288 Fungal Endophytes from Canadian Fruit Crops.ACS omega · 2023Article
- Comprehensive review on patulin andFrontiers in plant science · 2023Review
- Identification of a novel secreted metabolite cyclo(phenylalanyl-prolyl) from Batrachochytrium dendrobatidis and its effect on Galleria mellonella.BMC microbiology · 2022Article
- Differential Chemical Profile of Metabolite Extracts Produced by theMetabolites · 2022Article
- Epigenetic Activation of Silent Biosynthetic Gene Clusters in Endophytic Fungi Using Small Molecular Modifiers.Frontiers in microbiology · 2022Review
- Metabolomics analysis of grains of wheat infected and noninfected with Tilletia controversa Kühn.Scientific reports · 2021Article
- Mass Spectrometry: A Rosetta Stone to Learn How Fungi Interact and Talk.Life (Basel, Switzerland) · 2020Review
- Evaluation of Matrix Effects and Extraction Efficiencies of LC-MS/MS Methods as the Essential Part for Proper Validation of Multiclass Contaminants in Complex Feed.Journal of agricultural and food chemistry · 2020Article
- Identification of Secondary Metabolites fromMolecules (Basel, Switzerland) · 2020Article
- Unearthing fungal chemodiversity and prospects for drug discovery.Current opinion in microbiology · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Having entered the Genomic Era, it is now evident that the biosynthetic potential of filamentous fungi is much larger than was thought even a decade ago. Fungi harbor many cryptic gene clusters encoding for the biosynthesis of polyketides, non-ribosomal peptides, and terpenoids - which can all undergo extensive modifications by tailoring enzymes - thus potentially providing a large array of products from a single pathway. Elucidating the full chemical profile of a fungal species is a challenging exercise, even with elemental composition provided by high-resolution mass spectrometry (HRMS) used in combination with chemical databases (e.g., AntiBase) to dereplicate known compounds. This has led to a continuous effort to improve chromatographic separation in conjunction with improvement in HRMS detection. Major improvements have also occurred with 2D chromatography, ion-mobility, MS/MS and MS(3), stable isotope labeling feeding experiments, classic UV/Vis, and especially automated data-mining and metabolomics software approaches as the sheer amount of data generated is now the major challenge. This review will focus on the development and implementation of dereplication strategies and will highlight the importance of each stage of the process from sample preparation to chromatographic separation and finally toward both manual and more targeted methods for automated dereplication of fungal natural products using state-of-the art MS instrumentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.