ReviewFrontiers in endocrinology2015
Pediatric adrenocortical tumors: what they can tell us on adrenal development and comparison with adult adrenal tumors.
Review in Frontiers in endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- CpG hypermethylation and WNT/AP-1 cooperativity define the epigenetic landscape and a clinical subgroup of high-risk pediatric adrenocortical carcinoma.Nature communications · 2026Article
- Novel Insights Large Estrogen and Cortisol Co-Secreting Adrenocortical Tumor in a 17-Year-Old Female: A Case Report and Literature Review.Hormone research in paediatrics · 2026Article
- Case Report: Androgen-secreting pediatric adrenocortical tumor of uncertain malignant potential presenting with virilization in a 19-month-old girl.Frontiers in endocrinology · 2026Article
- Adrenal Tumors in Children and Adolescents in Sweden: A Register-Based Study Covering 15 Years.Journal of the Endocrine Society · 2025Article
- Adrenocortical tumors in children: Sri Lankan experience from a single center, and a mini review.Journal of medical case reports · 2023Review
- Retrospective Analysis of Prognostic Factors in Pediatric Patients with Adrenocortical Tumor from Unique Tertiary Center with Long-Term Follow-Up.Journal of clinical medicine · 2022Review
- Radiotherapy for pediatric adrenocortical carcinoma - Review of the literature.Clinical and translational radiation oncology · 2022Review
- Pathological and Genetic Stratification for Management of Adrenocortical Carcinoma.The Journal of clinical endocrinology and metabolism · 2022Review
- Feminizing Adrenocortical Tumors as a Rare Etiology of Isosexual/Contrasexual PseudopubertyJournal of clinical research in pediatric endocrinology · 2022Review
- Pediatric adrenocortical carcinoma.Frontiers in endocrinology · 2022Review
- Imaging findings of primary adrenal tumors in pediatric patients.Diagnostic and interventional radiology (Ankara, Turkey) · 2021Article
- Review
- Clinical Impact of Pathological Features Including the Ki-67 Labeling Index on Diagnosis and Prognosis of Adult and Pediatric Adrenocortical Tumors.Endocrine pathology · 2021Article
- Article
- Adrenocortical Carcinoma Steroid Profiles:Frontiers in endocrinology · 2021Article
- A RareCancer research · 2020Article
- Article
- Clinical, Genetic, and Prognostic Features of Adrenocortical Tumors in Children: A 10-Year Single-Center Experience.Frontiers in oncology · 2020Article
- The Prognostic Role of CD8Cancers · 2019Article
- Apoptosis regulation in adrenocortical carcinoma.Endocrine connections · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenocortical tumors (ACT) in children are very rare and are most frequently diagnosed in the context of the Li-Fraumeni syndrome, a multiple cancer syndrome linked to germline mutations of the tumor suppressor gene TP53 with loss of heterozygosity in the tumors. A peak of children ACT incidence is present in the states of southern Brazil, where they are linked to the high prevalence in the population of a specific TP53 mutation (R337H). Children ACT have specific features distinguishing them from adult tumors in their pathogenetic mechanisms, genomic profiles, and prognosis. Epidemiological and molecular evidence suggests that in most cases they are derived from the fetal adrenal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.