ReviewFrontiers in neurology2015
Maladaptive neural synchrony in tinnitus: origin and restoration.
Review in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss: Is There a Maladaptive Signature of Auditory Cortex GABA Loss and Dysconnectivity?
Personalized Music-embedded Sound Therapy Based on Gating Modulation and Neural Decoupling Reduces Tinnitus Severity in Adults Between 18 and 75 Years, With Chronic Tinnitus, Assessed With Tinnitus Handicap Inventory (THI)
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Efficacy of tailor-made notched music training (TMNMT) in the treatment of tinnitus: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Pooled it
- RTMS parameters in tinnitus trials: a systematic review.Scientific reports · 2019Pooled it
- Tailor-made notched music training-induced residual inhibition in subjective tinnitus: resting-state EEG spectral power ratio evidence.Frontiers in neuroscience · 2026Trial
- Modulated Alpha Power as a Predictor of Tinnitus Alleviation.The journal of international advanced otology · 2024Trial
- Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal Tinnitus.BioMed research international · 2015Trial
- Tinnitus Phenotypes and Their Response to the Enriched Acoustic Environment (EAE) Treatment.Brain sciences · 2026Article
- Personalized Music-Embedded Sound Therapy Based on Gating Modulation and Neural Decoupling Reduces Tinnitus Severity.Brain sciences · 2026Article
- Prolonged P3 latency predicts clinical response to repetitive transcranial magnetic stimulation in tinnitus.Clinical neurophysiology practice · 2026Article
- A Neuron-Like Cellular Model for Severe Tinnitus Associated with Rare Variations in the ANK2 Gene.Molecular neurobiology · 2025Article
- Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach.Scientific reports · 2025Article
- The Coexistence of Tinnitus and Temporomandibular Disorder: A Narrative Review on the Importance of an Interdisciplinary Approach.Journal of clinical medicine · 2024Review
- Subcortical auditory system in tinnitus with normal hearing: insights from electrophysiological perspective.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Phenotypic spectrum of tinnitus patients bearing rare ANK2 gene variants.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Enriched Acoustic Environment as a customized treatment for tinnitus: A non-controlled longitudinal study.Journal of otology · 2024Article
- Application of functional near-infrared spectroscopy (fNIRS) in tinnitus research: contemporary insights and perspectives.Frontiers in psychology · 2024Article
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics.Frontiers in neuroscience · 2023Article
- Comparison of Tinnitus Handicap Inventory and Tinnitus Functional Index as Treatment Outcomes.Audiology research · 2022Article
- Special Issue "New Insights into Pathophysiology, Diagnosis and Treatment of Tinnitus".Brain sciences · 2022Article
- Post-Mortem Analysis of Neuropathological Changes in Human Tinnitus.Brain sciences · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus is the conscious perception of sound heard in the absence of physical sound sources external or internal to the body, reflected in aberrant neural synchrony of spontaneous or resting-state brain activity. Neural synchrony is generated by the nearly simultaneous firing of individual neurons, of the synchronization of membrane-potential changes in local neural groups as reflected in the local field potentials, resulting in the presence of oscillatory brain waves in the EEG. Noise-induced hearing loss, often resulting in tinnitus, causes a reorganization of the tonotopic map in auditory cortex and increased spontaneous firing rates and neural synchrony. Spontaneous brain rhythms rely on neural synchrony. Abnormal neural synchrony in tinnitus appears to be confined to specific frequency bands of brain rhythms. Increases in delta-band activity are generated by deafferented/deprived neuronal networks resulting from hearing loss. Coordinated reset (CR) stimulation was developed in order to specifically counteract such abnormal neuronal synchrony by desynchronization. The goal of acoustic CR neuromodulation is to desynchronize tinnitus-related abnormal delta-band oscillations. CR neuromodulation does not require permanent stimulus delivery in order to achieve long-lasting desynchronization or even a full-blown anti-kindling but may have cumulative effects, i.e., the effect of different CR epochs separated by pauses may accumulate. Unlike other approaches, acoustic CR neuromodulation does not intend to reduce tinnitus-related neuronal activity by employing lateral inhibition. The potential efficacy of acoustic CR modulation was shown in a clinical proof of concept trial, where effects achieved in 12 weeks of treatment delivered 4-6 h/day persisted through a preplanned 4-week therapy pause and showed sustained long-term effects after 10 months of therapy, leading to 75% responders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.