Evidence map›Paper›PMID 25741279›Full record

ArticleFrontiers in aging neuroscience2015

Bone mineral density, adiposity, and cognitive functions.

Hamid R Sohrabi, Kristyn A Bates, Michael Weinborn, Romola S Bucks, Stephanie R Rainey-Smith, Mark A Rodrigues, Sabine M Bird, Belinda M Brown, John Beilby, Matthew Howard and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Hamid R SohrabiSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia ; School of Psychiatry and Clinical Neurosciences, University of Western Australia Crawley, Australia.
Kristyn A BatesThe McCusker Alzheimer's Research Foundation Nedlands, WA, Australia ; The School of Animal Biology, University of Western Australia Crawley, WA, Australia.
Michael WeinbornThe McCusker Alzheimer's Research Foundation Nedlands, WA, Australia ; School of Psychology, University of Western Australia Crawley, WA, Australia.
Romola S BucksSchool of Psychology, University of Western Australia Crawley, WA, Australia.
Stephanie R Rainey-SmithSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Mark A RodriguesSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Sabine M BirdThe McCusker Alzheimer's Research Foundation Nedlands, WA, Australia ; School of Psychiatry and Clinical Neurosciences, University of Western Australia Crawley, Australia.
Belinda M BrownSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
John BeilbySchool of Pathology and Laboratory Medicine, University of Western Australia Nedlands, WA, Australia ; PathWest Laboratory Medicine of WA Nedlands, WA, Australia.
Matthew HowardThe McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Arthur CriddleWestern Medicine, Hollywood Specialist Centre Nedlands, WA, Australia.
Megan WraithWestern Medicine, Hollywood Specialist Centre Nedlands, WA, Australia.
Kevin TaddeiSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Georgia MartinsSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Athena PatonSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Tejal ShahSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Satvinder S DhaliwalSchool of Public Health, Curtin University of Technology Perth, WA, Australia.
Pankaj D MehtaDivision of Immunology, Department of Developmental Neurobiolog,Institute for Basic Research in Developmental Disabilities Staten Island, NY, USA.
Jonathan K FosterNeurosciences Unit, Health Department of WA, School of Psychology and Speech Pathology, Curtin University of Technology Perth, WA, Australia.
Ian J MartinsSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Nicola T LautenschlagerSchool of Psychiatry and Clinical Neurosciences, University of Western Australia Crawley, Australia ; Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne Parkville, VIC, Australia ; The WA Centre for Health and Ageing, University of Western Australia Crawley, Australia.
Francis MastagliaInstitute for Immunology and Infectious Diseases, Murdoch University WA, Australia.
Simon M LawsSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia.
Ralph N MartinsSchool of Medical Sciences, Edith Cowan University Joondalup, WA, Australia ; The McCusker Alzheimer's Research Foundation Nedlands, WA, Australia ; School of Psychiatry and Clinical Neurosciences, University of Western Australia Crawley, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive decline and dementia due to Alzheimer's disease (AD) have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages are investigated. Bone mineral density (BMD) and body composition are two such potentially modifiable risk factors, and their association with cognitive decline was investigated in this study. 164 participants, aged 34-87 years old (62.78 ± 9.27), were recruited for this longitudinal study and underwent cognitive and clinical examinations at baseline and after 3 years. Blood samples were collected for apolipoprotein E (APOE) genotyping and dual energy x-ray absorptiometry (DXA) was conducted at the same day as cognitive assessment. Using hierarchical regression analysis, we found that BMD and lean body mass, as measured using DXA were significant predictors of episodic memory. Age, gender, APOE status, and premorbid IQ were controlled for. Specifically, the List A learning from California Verbal Learning Test was significantly associated with BMD and lean mass both at baseline and at follow up assessment. Our findings indicate that there is a significant association between BMD and lean body mass and episodic verbal learning. While the involvement of modifiable lifestyle factors in human cognitive function has been examined in different studies, there is a need for further research to understand the potential underlying mechanisms.

Indexed as

agingapolipoprotein Ebone mineral densitycognitiondual energy x-ray absorptiometryepisodic verbal memoryexecutive function

Identifiers

PMID25741279
PMCPMC4332358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.