Evidence map›Paper›PMID 25741267›Full record

ArticleFrontiers in human neuroscience2015

Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.

Olivier Dupuy, Claudine J Gauthier, Sarah A Fraser, Laurence Desjardins-Crèpeau, Michèle Desjardins, Said Mekary, Frederic Lesage, Rick D Hoge, Philippe Pouliot, Louis Bherer

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04635462 (The Cognitive and spOrt Virtual EPIC Training Study), which is not on this map. Cited by 108 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04635462 nacompletednot on this mapstarted 2020, after this paper: background citation

The Cognitive and spOrt Virtual EPIC Training Study: INVESTIGATING THE EFFECTS OF HOME-BASED EXERCISE AND COGNITIVE TRAINING

TypeinterventionalSponsorLouis BhererRan2020 to 2022Enrolled127ConditionsAgingArmsPhysical exercise training, Cognitive training
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olivier DupuyCentre PERFORM, Université Concordia Montreal, QC, Canada ; Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Laboratoire MOVE (EA6314), Faculté des Sciences du Sport de Poitiers, Université de Poitiers Poitiers, France.
Claudine J GauthierCentre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
Sarah A FraserCentre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Department of Social Work, McGill University Montreal, QC, Canada.
Laurence Desjardins-CrèpeauCentre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada.
Michèle DesjardinsCentre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Departement de Physiologie, Université de Montréal Montreal, QC, Canada.
Said MekaryCentre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada.
Frederic LesageÉcole Polytechnique de Montréal Montreal, QC, Canada.
Rick D HogeCentre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Departement de Physiologie, Université de Montréal Montreal, QC, Canada.
Philippe PouliotÉcole Polytechnique de Montréal Montreal, QC, Canada.
Louis BhererCentre PERFORM, Université Concordia Montreal, QC, Canada ; Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimMany studies have suggested that physical exercise training improves cognition and more selectively executive functions. There is a growing interest to clarify the neurophysiological mechanisms that underlie this effect. The aim of the current study was to evaluate the neurophysiological changes in cerebral oxygenation associated with physical fitness level and executive functions.

methodIn this study, 22 younger and 36 older women underwent a maximal graded continuous test (i.e., [Formula: see text]O2max ) in order to classify them into a fitness group (higher vs. lower fit). All participants completed neuropsychological paper and pencil testing and a computerized Stroop task (which contained executive and non-executive conditions) in which the change in prefrontal cortex oxygenation was evaluated with near infrared spectroscopy (NIRS).

resultsOur findings revealed a Fitness × Condition interaction (p < 0.05) such that higher fit women scored better on measures of executive functions than lower fit women. In comparison to lower fit women, higher fit women had faster reaction times in the Executive condition of the computerized Stroop task. No significant effect was observed in the non-executive condition of the test and no interactions were found with age. In measures of cerebral oxygenation (ΔHbT and ΔHbO2), we found a main effect of fitness on cerebral oxygenation during the Stroop task such that only high fit women demonstrated a significant increase in the right inferior frontal gyrus. DISCUSSION/

conclusionHigher fit individuals who demonstrate better cardiorespiratory functions (as measured by [Formula: see text]O2max ) show faster reaction times and greater cerebral oxygenation in the right inferior frontal gyrus than women with lower fitness levels. The lack of interaction with age, suggests that good cardiorespiratory functions can have a positive impact on cognition, regardless of age.

Indexed as

cerebral oxygenationexecutive functionfitnessprefrontal cortexright inferior frontal gyrusstroop

Identifiers

PMID25741267
PMCPMC4332308

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.