Evidence map›Paper›PMID 25741237›Full record

ArticleFrontiers in cellular neuroscience2015

Ontogeny of CX3CR1-EGFP expressing cells unveil microglia as an integral component of the postnatal subventricular zone.

Anna L Xavier, Flavia R S Lima, Maiken Nedergaard, João R L Menezes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Glial cells in the mammalian olfactory bulb.Frontiers in cellular neuroscience · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. The behavior and functions of embryonic microglia.Anatomical science international · 2022
    Review
  11. Article
  12. Review
  13. Review
  14. The Role of Microglia in Glioblastoma.Frontiers in oncology · 2020
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Role of microglia in embryonic neurogenesis.Experimental biology and medicine (Maywood, N.J.) · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Anna L XavierPrograma em Ciências Morfológicas, Programa de Diferenciação Celular, Laboratório de Neuroanatomia Celular, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil ; Center for Translational Neuromedicine, University of Rochester Medical School Rochester, NY, USA.
Flavia R S LimaLaboratório de Morfogênese Celular, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.
Maiken NedergaardCenter for Translational Neuromedicine, University of Rochester Medical School Rochester, NY, USA.
João R L MenezesPrograma em Ciências Morfológicas, Programa de Diferenciação Celular, Laboratório de Neuroanatomia Celular, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.
Universidade Federal do Rio de Janeiro · BRUniversity of Rochester · US

Funding

Glymphatic function in a transgenic rat model of Alzheimer's diseaseR01AG048769 · NIA · UNIVERSITY OF ROCHESTER · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2014 to 2018
$1.4M
NIA NIH HHS R01 AG048769
6 · The paper itself

Abstract

The full spectrum of cellular interactions within CNS neurogenic niches is still poorly understood. Only recently has the monocyte counterpart of the nervous system, the microglial cells, been described as an integral cellular component of neurogenic niches. The present study sought to characterize the microglia population in the early postnatal subventricular zone (SVZ), the major site of postnatal neurogenesis, as well as in its anterior extension, the rostral migratory stream (RMS), a pathway for neuroblasts during their transit toward the olfactory bulb (OB) layers. Here we show that microglia within the SVZ/RMS pathway are not revealed by phenotypic markers that characterize microglia in other regions. Analysis of the transgenic mice strain that has one locus of the constitutively expressed fractalkine CX3CR1 receptor replaced by the gene encoding the enhanced green fluorescent protein (EGFP) circumvented the antigenic plasticity of the microglia, thus allowing us to depict microglia within the SVZ/RMS pathway during early development. Notably, microglia within the early SVZ/RMS are not proliferative and display a protracted development, retaining a more immature morphology than their counterparts outside germinal layers. Furthermore, microglia contact and phagocyte radial glia cells (RG) processes, thereby playing a role on the astroglial transformation that putative stem cells within the SVZ niche undergo during the first postnatal days.

Indexed as

CX3CR1microglianeurogenesisrostral migratory streamsubventricular zone

Identifiers

PMID25741237
PMCPMC4330885
OpenAlexW1969340110

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.