ArticleProteome science2015
Proteome changes in the small intestinal mucosa of broilers (Gallus gallus) induced by high concentrations of atmospheric ammonia.
Article in Proteome science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mechanistic Approaches to the Application of Nano-Zinc in the Poultry and Biomedical Industries: A Comprehensive Review of Future Perspectives and Challenges.Molecules (Basel, Switzerland) · 2023Review
- Article
- High ambient humidity aggravates ammonia-induced respiratory mucosal inflammation by eliciting Th1/Th2 imbalance and NF-κB pathway activation in laying hens.Poultry science · 2022Article
- Role of Physiology, Immunity, Microbiota, and Infectious Diseases in the Gut Health of Poultry.Vaccines · 2022Review
- Applied Proteomics in 'One Health'.Proteomes · 2021Review
- Effects of Ammonia on Gut Microbiota and Growth Performance of Broiler Chickens.Animals : an open access journal from MDPI · 2021Article
- Protective effect of dietary supplementation of Bupleurum falcatum L saikosaponins on ammonia exposure-induced ileum injury in broilers.Poultry science · 2021Article
- PTEN/AKT/mTOR pathway involvement in autophagy, mediated by miR-99a-3p and energy metabolism in ammonia-exposed chicken bursal lymphocytes.Poultry science · 2021Article
- Disruption of cytochrome P450 enzymes in the liver and small intestine in chicken embryos in ovo exposed to glyphosate.Environmental science and pollution research international · 2020Article
- Effects of ammonia exposure on growth performance and cytokines in the serum, trachea, and ileum of broilers.Poultry science · 2020Article
- Impact of in ovo administered pioneer colonizers on intestinal proteome on day of hatch.Poultry science · 2020Article
- Physiological impact on layer chickens fed corn distiller's dried grains with solubles naturally contaminated with deoxynivalenol.Asian-Australasian journal of animal sciences · 2020Article
- Ammonia Exposure Induced Cilia Dysfunction of Nasal Mucosa in the Piglets.BioMed research international · 2020Article
- Ammonia exposure induced abnormal expression of cytokines and heat shock proteins via glucose metabolism disorders in chicken neutrophils.Environmental science and pollution research international · 2019Article
- Oxidative Stress in the Poultry Gut: Potential Challenges and Interventions.Frontiers in veterinary science · 2019Review
- Article
- Proteomic Analysis Revealed the Fruiting-Body Protein Profile of Auricularia polytricha.Current microbiology · 2017Article
- Maternal nutrition modulates fetal development by inducing placental efficiency changes in gilts.BMC genomics · 2017Article
- Proteomic Analysis of Chicken Skeletal Muscle during Embryonic Development.Frontiers in physiology · 2017Article
- Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS.Science China. Life sciences · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmmonia is a well-known toxicant both existing in atmospheric and aquatic system. So far, most studies of ammonia toxicity focused on mammals or aquatic animals. With the development of poultry industry, ammonia as a main source of contaminant in the air is causing more and more problems on broiler production, especially lower growth rate. The molecular mechanisms that underlie the negative effects of ammonia on the growth and intestine of broilers are yet unclear. We investigated the growth, gut morphology, and mucosal proteome of Arbor Acres broilers (Gallus gallus) exposed to high concentrations of atmospheric ammonia by performing a proteomics approach integrated with traditional methods.
resultsExposure to ammonia interfered with the development of immune organ and gut villi. Meanwhile, it greatly reduced daily weight gain and feed intake, and enhanced feed conversion ratio. A total of 43 intestinal mucosal proteins were found to be differentially abundant. Up-regulated proteins are related to oxidative phosphorylation and apoptosis. Down-regulated proteins are related to cell structure and growth, transcriptional and translational regulation, immune response, oxidative stress and nutrient metabolism. These results indicated that exposure to ammonia triggered oxidative stress, and interfered with nutrient absorption and immune function in the small intestinal mucosa of broilers.
conclusionsThese findings have important implications for understanding the toxic mechanisms of ammonia on intestine of broilers, which provides new information that can be used for intervention using nutritional strategies in the future.
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