Evidence map›Paper›PMID 25741214›Full record

ArticleBalkan journal of medical genetics : BJMG2014

Does the A9285G Polymorphism in Collagen Type XII α1 Gene Associate with the Risk of Anterior Cruciate Ligament Ruptures?

K Ficek, M Stepien-Slodkowska, M Kaczmarczyk, A Maciejewska-Karlowska, M Sawczuk, J Cholewinski, A Leonska-Duniec, A Zarebska, P Cieszczyk, P Zmijewski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Balkan journal of medical genetics : BJMG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Antioxidants (Basel, Switzerland) · 2026
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  7. Association ofBiomedicines · 2022
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  8. Review
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  11. Genes · 2021
    Article
  12. Review
  13. TheBiology of sport · 2019
    Article
  14. AreJournal of sports science & medicine · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

K FicekGalen Orthopaedics, Bieruń, Poland.
M Stepien-SlodkowskaDepartment of Physical Culture and Health Promotion, University of Szczecin, Poland.
M KaczmarczykDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.
A Maciejewska-KarlowskaDepartment of Genetics, University of Szczecin, Szczecin, Poland.
M SawczukDepartment of Genetics, University of Szczecin, Szczecin, Poland.
J CholewinskiGalen Orthopaedics, Bieruń, Poland ; Boni Fratres Catoviensis, Katowice, Poland.
A Leonska-DuniecDepartment of Physical Culture and Health Promotion, University of Szczecin, Poland.
A ZarebskaDepartment of Sport Education, Academy of Physical Education and Sport, Gdańsk, Poland.
P CieszczykDepartment of Physical Culture and Health Promotion, University of Szczecin, Poland.
P ZmijewskiDepartment of Physiology, Institute of Sport, Warsaw, Poland.
University of Szczecin · PLGdansk University of Physical Education and Sport · PLInstytut Sportu · PLPomeranian Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most severe injuries sustained by athletes is rupture of the anterior cruciate ligament (ACL). Recent investigations suggest that a predisposition for ACL rupture may be the result of specific genetic sequence variants. In light of this, we decided to investigate whether the COL12A1 A9285G polymorphism was associated with ACL ruptures in Polish football players. We compared genotypic and allelic frequencies of the COL12A1 A9285G polymorphism in two groups of athletes: 91 male football players (23 ± 3 years) with surgically diagnosed primary ACL ruptures who qualified for ligament reconstruction (cases) and 143 apparently healthy, male football players of the same ethnicity, a similar age category, and a comparable level of exposure to ACL injury, who were without any self-reported history of ligament or tendon injury (controls). DNA samples extracted from the oral epithelial cells were genotyped by using a real-time polymerase chain reaction (Ri-Ti-PCR) method. The genotype distribution in the cases were not different from those in controls (p = 0.70). The frequency of the G allele was lower in the cases (18.1%) but not statistically significant (p = 0.40) when compared with controls (21.3%). Our results are in contradiction to the hypothesis that the COL12A1 A9285G polymorphism is associated with a predisposition for ACL injury. However, these conclusions should be supported with more experimental studies on COL12A1 polymorphisms.

Indexed as

Anterior cruciate ligament (ACL) ruptureCOL12A1 geneCollagenPolymorphism

Identifiers

PMID25741214
PMCPMC4347476
OpenAlexW2271569112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.