ArticleWorld journal of gastroenterology2015
Expression profile of polyunsaturated fatty acids in colorectal cancer.
Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Fatty Acid Heterogeneity in Colorectal Cancer: From Food Matrices to Targeted Interventions.Cancers · 2026Review
- [Comparative analysis of intestinal microbiota distribution characteristics based on metagenomics in patients with hepatitis B cirrhosis with or without ascites].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- The Pleiotropic Effects of Gut Microbiota in Colorectal Cancer Progression: How to Turn Foes into Friends.Cancers · 2023Article
- Dihomo-International journal of molecular sciences · 2023Review
- Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China.Nutrients · 2022Article
- Reprogrammed Lipid Metabolism and the Lipid-Associated Hallmarks of Colorectal Cancer.Cancers · 2022Review
- Identification of fatty acid metabolism-related lncRNAs in the prognosis and immune microenvironment of colon adenocarcinoma.Biology direct · 2022Article
- Lipid Metabolism Interplay in CRC-An Update.Metabolites · 2022Review
- Association between dietary fat intake and colorectal cancer: A multicenter case-control study in Iran.Frontiers in nutrition · 2022Article
- Effects of Dietary n-3 and n-6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis.International journal of molecular sciences · 2021Review
- Lipid metabolism in cancer: A systematic review.Journal of carcinogenesis · 2021Review
- Review
- Decreased Triacylglycerol Content and Elevated Contents of Cell Membrane Lipids in Colorectal Cancer Tissue: A Lipidomic Study.Journal of clinical medicine · 2020Article
- Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration.Cellular and molecular life sciences : CMLS · 2020Article
- Changes in lipids composition and metabolism in colorectal cancer: a review.Lipids in health and disease · 2019Review
- Article
- Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer.Oncology letters · 2019Article
- Chemical metabolomics for investigating the protective effectiveness ofRSC advances · 2018Article
- Arachidonic Acid Induces the Migration of MDA-MB-231 Cells by Activating Raft-associated Leukotriene B4 Receptors.Clinical cancer drugs · 2018Article
- The Complex Puzzle of Interactions Among Functional Food, Gut Microbiota, and Colorectal Cancer.Frontiers in oncology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between the metabolism of polyunsaturated fatty acids (PUFAs) and tumor-associated factors for predicting the outcome of colorectal carcinoma (CRC) in Chinese patients.
methodsFresh-frozen malignant and normal tissues from 82 Chinese patients with CRC were analyzed for PUFA composition using gas-liquid chromatography. The levels of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), prostaglandin E2 and platelet-derived growth factor (PDGF) were measured by enzyme-linked immunosorbent assay, and the levels of VEGF, p53 and Ki-67 were measured by immunohistochemistry.
resultsIn malignant tissue, compared with normal tissue, the levels of total ω-6 PUFAs (24.64%±3.41% vs 26.77%±3.37%, P=0.00) and linoleic acid (LA) (15.46%±3.51% vs 18.30%±2.83%, P<0.01) were lower, whereas the levels of total ω-3 PUFAs (1.58%±0.74% vs 1.35%±0.60%, P<0.01) and dihomo-gamma-linolenic acid (DGLA) (1.32%±0.69% vs 0.85%±0.29%, P<0.01) were significantly higher. The ratios of arachidonic acid (AA)/LA (0.53±0.22 vs 0.42±0.19, P<0.01) and AA/total ω-6 PUFAs (0.31±0.09 vs 0.27±0.10, P<0.01) were also significantly higher in malignant tissue. The levels of PDGF (353.10±148.85 pg/mL vs 286.09±104.91 pg/mL, P<0.01), COX-2 (125.21±70.29 ng/mL vs 67.06±42.22 ng/mL, P<0.01) and VEGF (357.11±128.76 pg/mL vs 211.38±99.47 pg/mL, P<0.01) were also higher in malignant tissue compared to normal tissue. COX-2 was inversely correlated with LA (R=-0.3244, P<0.05) and positively correlated with AA/total ω-6 PUFAs (R=0.3083, P<0.05) and AA/LA (R=0.3001, P<0.05). The tissue level of LA was highest in poorly differentiated tumors (19.9%±6.3%, P<0.05), while the ratio of AA/ω-3 PUFAs was lowest in these tumors (10.8±2.6, P<0.05). In VEGF-positive tumors, the level of LA was higher (16.2%±3.7% vs 13.9%±2.7%, P<0.01), while the AA/ω-3PUFA, AA/ω-6 PUFA, and AA/LA ratios were lower than in VEGF-negative tumors (5.0±1.8 vs 6.7±3.3, 0.30±0.09 vs 0.34±0.09, 0.50±0.21 vs 0.61±0.21, P<0.01).
conclusionThe metabolism of PUFAs may play an important role in the evolution of inflammation-driven tumorigenesis in CRC and may be considered a potential marker for prognosis.
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