ArticleJournal of experimental botany2015
Function of glutathione peroxidases in legume root nodules.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Telomere-to-telomere genome of Stylosanthes guianensis uncovers symbiotic adaptation to phosphorus-deficient soils.Genome biology · 2026Article
- Asphaltene biotransformation by a novel enzyme thiol peroxidase fromApplied and environmental microbiology · 2025Article
- Nitric Oxide Regulates Multiple Signal Pathways in Plants via ProteinCurrent issues in molecular biology · 2025Review
- Persulfidation of plant and bacteroid proteins is involved in legume nodule development and senescence.Journal of experimental botany · 2024Article
- Signaling by reactive molecules and antioxidants in legume nodules.The New phytologist · 2022Review
- Characterization ofAntioxidants (Basel, Switzerland) · 2022Article
- A Nodule-Localized Small Heat Shock Protein GmHSP17.1 Confers Nodule Development and Nitrogen Fixation in Soybean.Frontiers in plant science · 2022Article
- The key regulator LcERF056 enhances salt tolerance by modulating reactive oxygen species-related genes in Lotus corniculatus.BMC plant biology · 2021Article
- Molecular responses of legumes to abiotic stress: post-translational modifications of proteins and redox signaling.Journal of experimental botany · 2021Review
- GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer.Thoracic cancer · 2020Article
- A member of wheat class III peroxidase gene family, TaPRX-2A, enhanced the tolerance of salt stress.BMC plant biology · 2020Article
- Breakthroughs in the discovery and use of different peroxidase isoforms of microbial origin.AIMS microbiology · 2020Review
- Sulfate is transported at significant rates through the symbiosome membrane and is crucial for nitrogenase biosynthesis.Plant, cell & environment · 2019Article
- Involvement of Glutaredoxin and Thioredoxin Systems in the Nitrogen-Fixing Symbiosis between Legumes and Rhizobia.Antioxidants (Basel, Switzerland) · 2018Review
- Protein Carbonylation and Glycation in Legume Nodules.Plant physiology · 2018Article
- Genome-wide identification of glutathione peroxidase (GPX) gene family and their response to abiotic stress in cucumber.3 Biotech · 2018Article
- Sulfur Transport and Metabolism in Legume Root Nodules.Frontiers in plant science · 2018Review
- Chromium(VI) Toxicity in Legume Plants: Modulation Effects of Rhizobial Symbiosis.BioMed research international · 2018Review
- Glutathione affects the transport activity of Rhizobium leguminosarum 3841 and is essential for efficient nodulation.FEMS microbiology letters · 2017Article
- Identification of Salt Tolerance-related microRNAs and Their Targets in Maize (Frontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione peroxidases (Gpxs) are antioxidant enzymes not studied so far in legume nodules, despite the fact that reactive oxygen species are produced at different steps of the symbiosis. The function of two Gpxs that are highly expressed in nodules of the model legume Lotus japonicus was examined. Gene expression analysis, enzymatic and nitrosylation assays, yeast cell complementation, in situ mRNA hybridization, immunoelectron microscopy, and LjGpx-green fluorescent protein (GFP) fusions were used to characterize the enzymes and to localize each transcript and isoform in nodules. The LjGpx1 and LjGpx3 genes encode thioredoxin-dependent phospholipid hydroperoxidases and are differentially regulated in response to nitric oxide (NO) and hormones. LjGpx1 and LjGpx3 are nitrosylated in vitro or in plants treated with S-nitrosoglutathione (GSNO). Consistent with the modification of the peroxidatic cysteine of LjGpx3, in vitro assays demonstrated that this modification results in enzyme inhibition. The enzymes are highly expressed in the infected zone, but the LjGpx3 mRNA is also detected in the cortex and vascular bundles. LjGpx1 is localized to the plastids and nuclei, and LjGpx3 to the cytosol and endoplasmic reticulum. Based on yeast complementation experiments, both enzymes protect against oxidative stress, salt stress, and membrane damage. It is concluded that both LjGpxs perform major antioxidative functions in nodules, preventing lipid peroxidation and other oxidative processes at different subcellular sites of vascular and infected cells. The enzymes are probably involved in hormone and NO signalling, and may be regulated through nitrosylation of the peroxidatic cysteine essential for catalytic function.
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