ArticleProceedings. Biological sciences2015
Evolution of hosts paying manifold costs of defence.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Coevolution of host resistance and pathogen exploitation in a propagule-mediated infection model.PLoS computational biology · 2026Article
- Changes in gene regulation are associated with the evolution of resistance to a novel parasite.Frontiers in immunology · 2026Article
- Agent-based modelling reveals feedback loops and non-linearity between mating system evolution and disease dynamics.PloS one · 2025Article
- 'Re-Wilding' an Animal Model With Microbiota Shifts Immunity and Stress Gene Expression During Infection.Molecular ecology · 2025Article
- Dose-dependent interaction of parasites with tiers of host defense predicts "wormholes" that prolong infection at intermediate inoculum sizes.PLoS computational biology · 2024Article
- Links between Innate and Adaptive Immunity Can Favor Evolutionary Persistence of Immunopathology.Integrative and comparative biology · 2024Article
- The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure.PLoS pathogens · 2024Article
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Activation of immune defences against parasitoid wasps does not underlie the cost of infection.Frontiers in immunology · 2023Article
- The transition between acute and chronic infections in light of energy control: a mathematical model of energy flow in response to infection.Journal of the Royal Society, Interface · 2022Article
- Balancing sensitivity, risk, and immunopathology in immune regulation.Current opinion in insect science · 2022Review
- The evolution of powerful yet perilous immune systems.Trends in immunology · 2022Review
- Honey Bees (Apis mellifera Hymenoptera: Apidae) Preferentially Avoid Sugar Solutions Supplemented with Field-Relevant Concentrations of Hydrogen Peroxide Despite High Tolerance Limits.Journal of insect science (Online) · 2022Article
- Optimal immune specificity at the intersection of host life history and parasite epidemiology.PLoS computational biology · 2021Article
- Why leveraging sex differences in immune trade-offs may illuminate the evolution of senescence.Functional ecology · 2020Review
- A genotypic trade-off between constitutive resistance to viral infection and host growth rate.Evolution; international journal of organic evolution · 2018Article
- Schedule and magnitude of reproductive investment under immune trade-offs explains sex differences in immunity.Nature communications · 2018Article
- Mitochondrial Dysfunction and Infection Generate Immunity-Fecundity Tradeoffs in Drosophila.Integrative and comparative biology · 2018Article
- The evolution of constitutive and induced defences to infectious disease.Proceedings. Biological sciences · 2018Article
- Optimal foraging in seasonal environments: implications for residency of Australian flying foxes in food-subsidized urban landscapes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hosts are expected to incur several physiological costs in defending against parasites. These include constitutive energetic (or other resource) costs of a defence system, facultative resource costs of deploying defences when parasites strike, and immunopathological costs of collateral damage. Here, we investigate the evolution of host recovery rates, varying the source and magnitude of immune costs. In line with previous work, we find that hosts paying facultative resource costs evolve faster recovery rates than hosts paying constitutive costs. However, recovery rate is more sensitive to changes in facultative costs, potentially explaining why constitutive costs are hard to detect empirically. Moreover, we find that immunopathology costs which increase with recovery rate can erode the benefits of defence, promoting chronicity of infection. Immunopathology can also lead to hosts evolving low recovery rate in response to virulent parasites. Furthermore, when immunopathology reduces fecundity as recovery rate increases (e.g. as for T-cell responses to urogenital chlamydiosis), then recovery and reproductive rates do not covary as predicted in eco-immunology. These results suggest that immunopathological and resource costs have qualitatively different effects on host evolution and that embracing the complexity of immune costs may be essential for explaining variability in immune defence in nature.
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