ReviewProceedings. Biological sciences2015
An out-of-body experience: the extracellular dimension for the transmission of mutualistic bacteria in insects.
Review in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
170 citing papers in PubMed, 335 citations in OpenAlex.
- Yellow protein co-opted to sustain obligate symbiosis in leaf beetles.Nature communications · 2026Article
- The bacterial march toward symbiosis: on-ramps and off-ramps.Trends in microbiology · 2026Review
- Symbiont evolutionary history underpins quality to an insect host.Journal of insect science (Online) · 2026Article
- Complementary Microscopic and Metabarcoding Studies Allow for a Better Understanding of the Symbiotic Microbiome of Leafhopper Species Iassus lanio (Hemiptera, Cicadellidae).Microbial ecology · 2026Article
- The uropygial gland of the European hoopoe as a symbiotic organ.Animal microbiome · 2026Article
- A Comparative Survey of Soldier Fly (Stratiomyidae) Larval Gut Microbiomes Across Five Subfamilies Reveals Novel Bacterial Diversity and a "Wild Core" in Hermetia illucens.Microbial ecology · 2026Article
- Ecological Drivers of Microbiota Diversity in the Pharmacophagous Turnip Sawfly.Environmental microbiology · 2026Article
- The interplay between insect gut microbiota and host immunity in the development and dissemination of antibiotic resistance.Folia microbiologica · 2026Review
- Defensive symbionts of the European beewolf face competition from brood cell microbiota during vertical transmission.FEMS microbiology ecology · 2026Article
- Article
- Tryptophanase disruption promotes insect-bacterium mutualism.Nature microbiology · 2026Article
- Fidelity in co-diversified symbiosis.Nature communications · 2026Article
- Cockroach bacteriocytes migrate into the ovaries for vertical transmission of the bacterial endosymbiont Blattabacterium.Zoological letters · 2026Article
- Characterizing a Novel Symbiopectobacterium purcellii MEX Strain at the Early Stages of Establishing a Symbiotic Relationship.Genome biology and evolution · 2026Article
- Intraspecific microbiome dynamics across the life cycle of the milkweed bugMicrobial genomics · 2026Article
- Leaffooted bugs enrich local soil with their horizontally acquired symbiont.Frontiers in microbiology · 2026Article
- Late is not great: fitness implications of delayed symbiont acquisition.Frontiers in microbiology · 2026Article
- Editorial: Diversity of beetles and associated microorganisms, volume II.Frontiers in microbiology · 2026Article
- A New Classification Framework to Understand Evolutionary Transitions in Individuality.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Across animals and plants, numerous metabolic and defensive adaptations are a direct consequence of symbiotic associations with beneficial microbes. Explaining how these partnerships are maintained through evolutionary time remains one of the central challenges within the field of symbiosis research. While genome erosion and co-cladogenesis with the host are well-established features of symbionts exhibiting intracellular localization and transmission, the ecological and evolutionary consequences of an extracellular lifestyle have received little attention, despite a demonstrated prevalence and functional importance across many host taxa. Using insect-bacteria symbioses as a model, we highlight the diverse routes of extracellular symbiont transfer. Extracellular transmission routes are unified by the common ability of the bacterial partners to survive outside their hosts, thereby imposing different genomic, metabolic and morphological constraints than would be expected from a strictly intracellular lifestyle. We emphasize that the evolutionary implications of symbiont transmission routes (intracellular versus extracellular) do not necessarily correspond to those of the transmission mode (vertical versus horizontal), a distinction of vital significance when addressing the genomic and physiological consequences for both host and symbiont.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.