Evidence map›Paper›PMID 25740857›Full record

ArticleJournal of dental research2015

Oral disease profiles in chronic graft versus host disease.

C W Bassim, H Fassil, J W Mays, D Edwards, K Baird, S M Steinberg, E W Cowen, H Naik, M Datiles, P Stratton and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00331968, which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00331968 no registry record found
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. γδ T cells in oral diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Pooled it
  3. The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

C W BassimNational Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA carol.bassim@nih.gov.
H FassilExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA Tufts University School of Dental Medicine, Boston, MA, USA.
J W MaysNational Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA.
D EdwardsNational Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA.
K BairdPediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
S M SteinbergBiostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
E W CowenDermatology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
H NaikDermatology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
M DatilesNational Eye Institute, NIH, Bethesda, MD, USA.
P StrattonProgram in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
R E GressExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
S Z PavleticExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
National Cancer Institute · USNational Institute of Dental and Craniofacial Research · USCenter for Cancer Research · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Eye Institute · USTufts University · US

Funding

Immunobiology and therapy of oral mucosal and salivary gland chronic graft-versus-host diseaseZIADE000747 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MAYS, JACQUELINE · 2016 to 2025
$14.9M
NIDCR DIR Clinical TrainingZIEDE000727 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MAYS, JACQUELINE · 2009 to 2025
$6.8M
Chronic graft-versus-host diseaseZIABC011549 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI COWEN, EDWARD · 2014 to 2021
$5.2M
Safety and Immunogenicity of Gardasil post stem cell transplantationZIAHD008900 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATTON, PAMELA · 2010 to 2016
$1.2M
A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) PatientsZIAEY000540 · NEI · NATIONAL EYE INSTITUTE · PI DATILES, MANUEL B · 2014 to 2016
$795k
Intramural NIH HHS
6 · The paper itself

Abstract

At least half of patients with chronic graft-versus-host-disease (cGVHD), the leading cause of morbidity and non-relapse mortality after allogeneic stem cell transplantation, have oral manifestations: mucosal lesions, salivary dysfunction, and limited mouth-opening. cGVHD may manifest in a single organ or affect multiple organ systems, including the mouth, eyes, and the skin. The interrelationship of the 3 oral manifestations of cGVHD with each other and with the specific manifestations of extraoral cGVHD has not been studied. In this analysis, we explored, in a large group of patients with cGVHD, the potential associations between: (1) oral mucosal disease and erythematous skin disease, (2) salivary gland dysfunction and lacrimal gland dysfunction, and (3) limited mouth-opening and sclerotic skin cGVHD. Study participants, enrolled in a cGVHD Natural History Protocol (NCT00331968, n = 212), underwent an oral examination evaluating: (1) mucosal cGVHD [NIH Oral Mucosal Score (OMS)], (2) salivary dysfunction (saliva flow and xerostomia), and (3) maximum mouth-opening measurement. Parameters for dysfunction (OMS > 2, saliva flow ≤ 1 mL/5 min, mouth-opening ≤ 35 mm) were analyzed for association with skin cGVHD involvement (erythema and sclerosis, skin symptoms), lacrimal dysfunction (Schirmer's tear test, xerophthalmia), Lee cGVHD Symptom Scores, and NIH organ scores. Oral mucosal disease (31% prevalence) was associated with skin erythema (P < 0.001); salivary dysfunction (11% prevalence) was associated with lacrimal dysfunction (P = 0.010) and xerostomia with xerophthalmia (r = 0.32, P = 0.001); and limited mouth-opening (17% prevalence) was associated with skin sclerosis (P = 0.008) and skin symptoms (P = 0.001). There was no association found among these 3 oral cGVHD manifestations. This analysis supports the understanding of oral cGVHD as 3 distinct diseases: mucosal lesions, salivary gland dysfunction, and mouth sclerosis. Clear classification of oral cGVHD as 3 separate manifestations will improve clinical diagnosis, observational research data collection, and the definitions of outcome measures in clinical trials.

Indexed as

AdolescentAdultAgedBody Surface AreaChronic DiseaseCross-Sectional StudiesErythemaFemaleGraft vs Host DiseaseHumansLacrimal Apparatus DiseasesMaleMiddle AgedMouthMouth DiseasesMouth Mucosaautoimmune diseaseclinical researchoral cGVHDoral medicinesalivary dysfunctionstem cell transplantation

Identifiers

PMID25740857
PMCPMC4485216
OpenAlexW2097047560

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.