ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
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- Boosting reservoir computing with brain-inspired adaptive control of E-I balance.Nature communications · 2025Article
- Repetitive training enhances the pattern recognition capability of cultured neural networks.PLoS computational biology · 2025Article
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- Deviance detection and regularity sensitivity in dissociated neuronal cultures.Frontiers in neural circuits · 2025Article
- Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Biological neurons act as generalization filters in reservoir computing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- An Overview of In Vitro Biological Neural Networks for Robot Intelligence.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- An improved platform for cultured neuronal network electrophysiology: multichannel optogenetics integrated with MEAs.European biophysics journal : EBJ · 2022Article
- Leveraging plant physiological dynamics using physical reservoir computing.Scientific reports · 2022Article
- Spontaneous and Perturbational Complexity in Cortical Cultures.Brain sciences · 2021Article
- Sequence Learning Induces Selectivity to Multiple Task Parameters in Mouse Somatosensory Cortex.Current biology : CB · 2021Article
- Understanding the Impact of Neural Variations and Random Connections on Inference.Frontiers in computational neuroscience · 2021Article
- Collective almost synchronization-based model to extract and predict features of EEG signals.Scientific reports · 2020Article
- Encoding Temporal Regularities and Information Copying in Hippocampal Circuits.Scientific reports · 2019Article
- Evolutionary aspects of reservoir computing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures.Scientific reports · 2018Article
- How neuroscience can inform the study of individual differences in cognitive abilities.Reviews in the neurosciences · 2017Review
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4 authors.
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Abstract
The ability to process complex spatiotemporal information is a fundamental process underlying the behavior of all higher organisms. However, how the brain processes information in the temporal domain remains incompletely understood. We have explored the spatiotemporal information-processing capability of networks formed from dissociated rat E18 cortical neurons growing in culture. By combining optogenetics with microelectrode array recording, we show that these randomly organized cortical microcircuits are able to process complex spatiotemporal information, allowing the identification of a large number of temporal sequences and classification of musical styles. These experiments uncovered spatiotemporal memory processes lasting several seconds. Neural network simulations indicated that both short-term synaptic plasticity and recurrent connections are required for the emergence of this capability. Interestingly, NMDA receptor function is not a requisite for these short-term spatiotemporal memory processes. Indeed, blocking the NMDA receptor with the antagonist APV significantly improved the temporal processing ability of the networks, by reducing spontaneously occurring network bursts. These highly synchronized events have disastrous effects on spatiotemporal information processing, by transiently erasing short-term memory. These results show that the ability to process and integrate complex spatiotemporal information is an intrinsic property of generic cortical networks that does not require specifically designed circuits.
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