ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Dual mechanism for bitter avoidance in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 106 citations in OpenAlex.
- Article
- A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026Article
- Opponent coding mechanisms in Drosophila taste neurons.Chemical senses · 2025Review
- An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of GABA in modulation of taste signaling within the taste bud.Pflugers Archiv : European journal of physiology · 2024Article
- Article
- Taste Sensory Responses in Mosquitoes.Cold Spring Harbor protocols · 2024Article
- Sugar detection in 3D: Structure of an insect gustatory receptor.Cell reports · 2024Article
- Use of the Proboscis Extension Response Assay to Evaluate the Mechanism of House Fly Behavioral Resistance to Imidacloprid.Insects · 2024Article
- Mouthparts of the bumblebee (eLife · 2023Article
- Diverse mechanisms of taste coding inScience advances · 2023Article
- Adenosine triphosphate overrides the aversive effect of antifeedants and toxicants: a model alternative phagostimulant for sugar-based vector control tools.Parasites & vectors · 2023Article
- Acid and Alkali Taste Sensation.Metabolites · 2023Review
- Evolution of fatty acid taste in drosophilids.Cell reports · 2023Article
- Molecular Basis of Hexanoic Acid Taste inMolecules and cells · 2023Article
- Molecular sensors in the taste system of Drosophila.Genes & genomics · 2023Review
- A leaky integrate-and-fire computational model based on the connectome of the entire adultbioRxiv : the preprint server for biology · 2023Article
- Taste adaptations associated with host specialization in the specialist Drosophila sechellia.The Journal of experimental biology · 2023Article
- An inhibitory mechanism for suppressing high salt intake in Drosophila.Chemical senses · 2023Article
- Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa armigera.PLoS genetics · 2022Article
Corrections and comments
- Commented on by
- Erratum issuedMoutaz, Ali Agha [Corrected to Ali Agha, Moutaz]
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In flies and humans, bitter chemicals are known to inhibit sugar detection, but the adaptive role of this inhibition is often overlooked. At best, this inhibition is described as contributing to the rejection of potentially toxic food, but no studies have addressed the relative importance of the direct pathway that involves activating bitter-sensitive cells versus the indirect pathway represented by the inhibition of sugar detection. Using toxins to selectively ablate or inactivate populations of bitter-sensitive cells, we assessed the behavioral responses of flies to sucrose mixed with strychnine (which activates bitter-sensitive cells and inhibits sugar detection) or with L-canavanine (which only activates bitter-sensitive cells). As expected, flies with ablated bitter-sensitive cells failed to detect L-canavanine mixed with sucrose in three different feeding assays (proboscis extension responses, capillary feeding, and two-choice assays). However, such flies were still able to avoid strychnine mixed with sucrose. By means of electrophysiological recordings, we established that bitter molecules differ in their potency to inhibit sucrose detection and that sugar-sensing inhibition affects taste cells on the proboscis and the legs. The optogenetic response of sugar-sensitive cells was not reduced by strychnine, thus suggesting that this inhibition is linked directly to sugar transduction. We postulate that sugar-sensing inhibition represents a mechanism in insects to prevent ingesting harmful substances occurring within mixtures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.