ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Movement-related discharge in the macaque globus pallidus during high-frequency stimulation of the subthalamic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- A comparison of movement-related neuronal activities in cerebellar- and basal ganglia-recipient regions of the macaque thalamus.bioRxiv : the preprint server for biology · 2026Article
- Efficacy and safety of single-trajectory posterior subthalamic area and subthalamic nucleus deep brain stimulation for dystonic tremor: a retrospective pilot study.Journal of neurology · 2026Article
- Movement-related activity in the internal globus pallidus of the parkinsonian macaque.Journal of neurophysiology · 2025Article
- Article
- Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Intraoperative Characterization of Subthalamic Nucleus-to-Cortex Evoked Potentials in Parkinson's Disease Deep Brain Stimulation.Frontiers in human neuroscience · 2021Article
- Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication.PLoS biology · 2020Article
- Long-term labeling of microelectrode tracks with fluorescent latex microspheres.Journal of neuroscience methods · 2020Article
- Deep brain stimulation: current challenges and future directions.Nature reviews. Neurology · 2019Review
- Innovations in electrical stimulation harness neural plasticity to restore motor function.Bioelectronics in medicine · 2018Article
- Neuronal inhibition and synaptic plasticity of basal ganglia neurons in Parkinson's disease.Brain : a journal of neurology · 2018Article
- The human subthalamic nucleus and globus pallidus internus differentially encode reward during action control.Human brain mapping · 2017Article
- Locomotion-Related Population Cortical CaFrontiers in neural circuits · 2017Article
- Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.Frontiers in neuroscience · 2016Review
- Information in pallidal neurons increases with parkinsonian severity.Parkinsonism & related disorders · 2015Article
- Common therapeutic mechanisms of pallidal deep brain stimulation for hypo- and hyperkinetic movement disorders.Journal of neurophysiology · 2015Review
- Deep Brain Stimulation: Expanding Applications.Neurologia medico-chirurgica · 2015Review
- Modulation of Neuronal Activity in the Motor Thalamus during GPi-DBS in the MPTP Nonhuman Primate Model of Parkinson's Disease.Brain stimulationArticle
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4 authors at 3 institutions in 2 countries.
Funding
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) has largely replaced ablative therapies for Parkinson's disease. Because of the similar efficacies of the two treatments, it has been proposed that DBS acts by creating an "informational lesion," whereby pathologic neuronal firing patterns are replaced by low-entropy, stimulus-entrained firing patterns. The informational lesion hypothesis, in its current form, states that DBS blocks the transmission of all information from the basal ganglia, including both pathologic firing patterns and normal, task-related modulations in activity. We tested this prediction in two healthy rhesus macaques by recording single-unit spiking activity from the globus pallidus (232 neurons) while the animals completed choice reaction time reaching movements with and without STN-DBS. Despite strong effects of DBS on the activity of most pallidal cells, reach-related modulations in firing rate were equally prevalent in the DBS-on and DBS-off states. This remained true even when the analysis was restricted to cells affected significantly by DBS. In addition, the overall form and timing of perimovement modulations in firing rate were preserved between DBS-on and DBS-off states in the majority of neurons (66%). Active movement and DBS had largely additive effects on the firing rate of most neurons, indicating an orthogonal relationship in which both inputs contribute independently to the overall firing rate of pallidal neurons. These findings suggest that STN-DBS does not act as an indiscriminate informational lesion but rather as a filter that permits task-related modulations in activity while, presumably, eliminating the pathological firing associated with parkinsonism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.