ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Structure of a single whisker representation in layer 2 of mouse somatosensory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics.bioRxiv : the preprint server for biology · 2025Article
- Complicated architecture of cortical microcircuit: a comprehensive review.Anatomical science international · 2025Review
- Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity.bioRxiv : the preprint server for biology · 2025Article
- Degraded tactile coding in the Cntnap2 mouse model of autism.Cell reports · 2024Article
- Adapting and facilitating responses in mouse somatosensory cortex are dynamic and shaped by experience.Current biology : CB · 2024Article
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III.Nature communications · 2024Article
- The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation.Scientific reports · 2024Article
- Stochastic resonance in sparse neuronal network: functional role of ongoing activity to detect weak sensory input in awake auditory cortex of rat.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Cortical circuitry mediating interareal touch signal amplification.Cell reports · 2023Article
- Representational drift in barrel cortex is receptive field dependent.bioRxiv : the preprint server for biology · 2023Article
- VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals.Current biology : CB · 2023Article
- Article
- High fidelity sensory-evoked responses in neocortex after intravenous injection of genetically encoded calcium sensors.bioRxiv : the preprint server for biology · 2023Article
- Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing.PloS one · 2023Article
- High fidelity sensory-evoked responses in neocortex after intravenous injection of genetically encoded calcium sensors.Frontiers in neuroscience · 2023Article
- Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex.Nature communications · 2022Article
- A detailed behavioral, videographic, and neural dataset on object recognition in mice.Scientific data · 2022Article
- Transformation of primary sensory cortical representations from layer 4 to layer 2.Nature communications · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Layer (L)2 is a major output of primary sensory cortex that exhibits very sparse spiking, but the structure of sensory representation in L2 is not well understood. We combined two-photon calcium imaging with deflection of many whiskers to map whisker receptive fields, characterize sparse coding, and quantitatively define the point representation in L2 of mouse somatosensory cortex. Neurons within a column-sized imaging field showed surprisingly heterogeneous, salt-and-pepper tuning to many different whiskers. Single whisker deflection elicited low-probability spikes in highly distributed, shifting neural ensembles spanning multiple cortical columns. Whisker-evoked response probability correlated strongly with spontaneous firing rate, but weakly with tuning properties, indicating a spectrum of inherent responsiveness across pyramidal cells. L2 neurons projecting to motor and secondary somatosensory cortex differed in whisker tuning and responsiveness, and carried different amounts of information about columnar whisker deflection. From these data, we derive a quantitative, fine-scale picture of the distributed point representation in L2.
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