ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Spine loss in primary somatosensory cortex during trace eyeblink conditioning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Learning, prediction accuracy, and neural plasticity in sensory cortex.Current opinion in neurobiology · 2025Review
- Article
- Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Synaptic modifications in learning and memory - A dendritic spine story.Seminars in cell & developmental biology · 2022Review
- A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Spine dynamics of PSD-95-deficient neurons in the visual cortex link silent synapses to structural cortical plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.Frontiers in cellular neuroscience · 2021Article
- A method for combining multiple-units readout of optogenetic control with natural stimulation-evoked eyeblink conditioning in freely-moving mice.Scientific reports · 2019Article
- Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice.Scientific reports · 2018Article
- Functional and structural underpinnings of neuronal assembly formation in learning.Nature neuroscience · 2016Review
- Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice.Journal of visualized experiments : JoVE · 2016Article
- Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes in the Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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4 authors.
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Abstract
Classical conditioning that involves mnemonic processing, that is, a "trace" period between conditioned and unconditioned stimulus, requires awareness of the association to be formed and is considered a simple model paradigm for declarative learning. Barrel cortex, the whisker representation of primary somatosensory cortex, is required for the learning of a tactile variant of trace eyeblink conditioning (TTEBC) and undergoes distinct map plasticity during learning. To investigate the cellular mechanism underpinning TTEBC and concurrent map plasticity, we used two-photon imaging of dendritic spines in barrel cortex of awake mice while being conditioned. Monitoring layer 5 neurons' apical dendrites in layer 1, we show that one cellular expression of barrel cortex plasticity is a substantial spine count reduction of ∼15% of the dendritic spines present before learning. The number of eliminated spines and their time of elimination are tightly related to the learning success. Moreover, spine plasticity is highly specific for the principal barrel column receiving the main signals from the stimulated vibrissa. Spines located in other columns, even those directly adjacent to the principal column, are unaffected. Because layer 1 spines integrate signals from associative thalamocortical circuits, their column-specific elimination suggests that this spine plasticity may be the result of an association of top-down signals relevant for declarative learning and spatially precise ascending tactile signals.
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