ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 94 citations in OpenAlex.
- Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh syndrome mice.EMBO molecular medicine · 2026Article
- A transcriptomic atlas of astrocyte heterogeneity across space and time in mouse and marmoset.Neuron · 2025Article
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- Astrocyte regional specialization is shaped by postnatal development.bioRxiv : the preprint server for biology · 2025Article
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- Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter.Nature neuroscience · 2025Article
- Mechanisms of astrocyte aging in reactivity and disease.Molecular neurodegeneration · 2025Review
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- Intrinsic organization of the corpus callosum.Frontiers in physiology · 2024Review
- Glial Populations in the Human Brain Following Ischemic Injury.Biomedicines · 2023Review
- IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.Development (Cambridge, England) · 2023Article
- Differential contribution of TrkB and p75Frontiers in molecular neuroscience · 2023Article
- Intravital Imaging of the Murine Subventricular Zone with Three Photon Microscopy.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease.Molecular neurobiology · 2022Article
- Neuroanatomical and Immunohistological Study of the Main and Accessory Olfactory Bulbs of the Meerkat (Animals : an open access journal from MDPI · 2021Article
- Recent advances in tissue stem cells.Science China. Life sciences · 2021Review
- Aberrations of Genomic Imprinting in Glioblastoma Formation.Frontiers in oncology · 2021Review
- Astrocyte and Oligodendrocyte Responses From the Subventricular Zone After Injury.Frontiers in cellular neuroscience · 2021Review
- Developmental dynamics of neurogenesis and gliogenesis in the postnatal mammalian brain in health and disease: Historical and future perspectives.Wiley interdisciplinary reviews. Developmental biology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes are the most abundant cells in the CNS, and have many essential functions, including maintenance of blood-brain barrier integrity, and CNS water, ion, and glutamate homeostasis. Mammalian astrogliogenesis has generally been considered to be completed soon after birth, and to be reactivated in later life only under pathological circumstances. Here, by using genetic fate-mapping, we demonstrate that new corpus callosum astrocytes are continuously generated from nestin(+) subventricular zone (SVZ) neural progenitor cells (NPCs) in normal adult mice. These nestin fate-mapped corpus callosum astrocytes are uniformly postmitotic, express glutamate receptors, and form aquaporin-4(+) perivascular endfeet. The entry of new astrocytes from the SVZ into the corpus callosum appears to be balanced by astroglial apoptosis, because overall numbers of corpus callosum astrocytes remain constant during normal adulthood. Nestin fate-mapped astrocytes also flow anteriorly from the SVZ in association with the rostral migratory stream, but do not penetrate into the deeper layers of the olfactory bulb. Production of new astrocytes from nestin(+) NPCs is absent in the normal adult cortex, striatum, and spinal cord. Our study is the first to demonstrate ongoing SVZ astrogliogenesis in the normal adult mammalian forebrain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.