ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- α4 nicotinic receptors on GABAergic neurons mediate a cholinergic analgesic circuit in the substantia nigra pars reticulata.Acta pharmacologica Sinica · 2024Article
- Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease.Translational neurodegeneration · 2023Review
- Cell and circuit complexity of the external globus pallidus.Nature neuroscience · 2023Review
- Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice.Nature communications · 2023Article
- Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions.Acta pharmacologica Sinica · 2022Article
- Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes.Acta pharmacologica Sinica · 2022Article
- Article
- Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons.Neuroscience bulletin · 2020Article
- ParvalbuminThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function.Neuropharmacology · 2019Article
- The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Venom based neural modulators.Experimental and therapeutic medicine · 2018Article
- Differential Control of Dopaminergic Excitability and Locomotion by Cholinergic Inputs in Mouse Substantia Nigra.Current biology : CB · 2017Article
- Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice.Neurobiology of disease · 2016Article
- Npas1+ Pallidal Neurons Target Striatal Projection Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The external globus pallidus: progress and perspectives.The European journal of neuroscience · 2016Review
- Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways.Neuron · 2016Article
- Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.Neuropharmacology · 2015Review
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7 authors at 1 institution in 1 country.
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Abstract
The glutamatergic subthalamic nucleus (STN) exerts control over motor output through nuclei of the basal ganglia. High-frequency electrical stimuli in the STN effectively alleviate motor symptoms in movement disorders, and cholinergic stimulation boosts this effect. To gain knowledge about the mechanisms of cholinergic modulation in the STN, we studied cellular and circuit aspects of nicotinic acetylcholine receptors (nAChRs) in mouse STN. We discovered two largely divergent microcircuits in the STN; these are regulated in part by either α4β2 or α7 nAChRs. STN neurons containing α4β2 nAChRs (α4β2 neurons) received more glutamatergic inputs, and preferentially innervated GABAergic neurons in the substantia nigra pars reticulata. In contrast, STN neurons containing α7 nAChRs (α7 neurons) received more GABAergic inputs, and preferentially innervated dopaminergic neurons in the substantia nigra pars compacta. Interestingly, local electrical stimuli excited a majority (79%) of α4β2 neurons but exerted strong inhibition in 58% of α7 neurons, indicating an additional diversity of STN neurons: responses to electrical stimulation. Chronic exposure to nicotine selectively affects α4β2 nAChRs in STN: this treatment increased the number of α4β2 neurons, upregulated α4-containing nAChR number and sensitivity, and enhanced the basal firing rate of α4β2 neurons both ex vivo and in vivo. Thus, chronic nicotine enhances the function of the microcircuit involving α4β2 nAChRs. This indicates chronic exposure to nicotinic agonist as a potential pharmacological intervention to alter selectively the balance between these two microcircuits, and may provide a means to inhibit substantia nigra dopaminergic neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.