ArticleNanotoxicology2016
Molecular toxicity of cerium oxide nanoparticles to the freshwater alga Chlamydomonas reinhardtii is associated with supra-environmental exposure concentrations.
Article in Nanotoxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 88 citations in OpenAlex.
- Cerium-Modified Diatom Biosilica for Lithium-Ion Anodes.ACS omega · 2026Article
- Microalgae-Mediated Nanotechnology for Sustainable Agriculture: Applications, Advances, and Future Prospects.International journal of molecular sciences · 2026Review
- Morphophysiological, biochemical, and nutrient response of spinach (Spinacia oleracea L.) by foliar CeOScientific reports · 2024Article
- Application of Nanomaterials in the Production of Biomolecules in Microalgae: A Review.Marine drugs · 2023Review
- Review
- The toxicity of nanoparticles and their interaction with cells: anNanoscale advances · 2023Review
- Evaluation of Apical and Molecular Effects of AlgaeToxics · 2023Article
- Response of Soil Bacterial Diversity, Predicted Functions and Co-Occurrence Patterns to Nanoceria and Ionic Cerium Exposure.Microorganisms · 2022Article
- Insights on the Dynamics and Toxicity of Nanoparticles in Environmental Matrices.Bioinorganic chemistry and applications · 2022Review
- Nanostructured Ceria: Biomolecular Templates and (Bio)applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Nanoimpact in Plants: Lessons from the Transcriptome.Plants (Basel, Switzerland) · 2021Review
- Harmful effects of metal(loid) oxide nanoparticles.Applied microbiology and biotechnology · 2021Review
- Ecological and toxicological assessments of anthropogenic contaminants based on environmental metabolomics.Environmental science and ecotechnology · 2021Review
- Applications of nano-materials in diverse dentistry regimes.RSC advances · 2020Review
- Evaluation of Ecotoxicology Assessment Methods of Nanomaterials and Their Effects.Nanomaterials (Basel, Switzerland) · 2020Review
- Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis.Nanomaterials (Basel, Switzerland) · 2020Review
- Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague-Dawley rats.Nanotoxicology · 2019Article
- Improved Algal Toxicity Test System for RobustMetabolites · 2019Article
- Douglas-Fir ( Pseudotsuga menziesii (Mirb.) Franco) Transcriptome Profile Changes Induced by Diesel Emissions Generated with CeOEnvironmental science & technology · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ceria nanoparticles (NPs) are widely used as fuel catalysts and consequently are likely to enter the environment. Their potential impacts on. biota at environmentally relevant concentrations, including uptake and toxicity, remain to be elucidated and quantitative data on which to assess risk are sparse. Therefore, a definitive assessment of the molecular and phenotypic effects of ceria NPs was undertaken, using well-characterised mono-dispersed NPs as their toxicity is likely to be higher, enabling a conservative hazard assessment. Unbiased transcriptomics and metabolomics approaches were used to investigate the potential toxicity of tightly constrained 4-5 nm ceria NPs to the unicellular green alga, Chlamydomonas reinhardtii, a sentinel freshwater species. A wide range of exposure concentrations were investigated from predicted environmental levels, to support hazard assessment, to supra-environmental levels to provide insight into molecular toxicity pathways. Ceria NPs were internalised into intracellular vesicles within C. reinhardtii, yet caused no significant effect on algal growth at any exposure concentration. Molecular perturbations were only detected at supra-environmental ceria NP-concentrations, primarily down-regulation of photosynthesis and carbon fixation with associated effects on energy metabolism. For acute exposures to small mono-dispersed particles, it can be concluded there should be little concern regarding their dispersal into the environment for this trophic level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.