ArticleLasers in surgery and medicine2015
High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography.
Article in Lasers in surgery and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Atrophic Acne Scar Risk and Reflectance Confocal Microscopy Predictive Features.Journal of cosmetic dermatology · 2026Article
- Design and implementation of an integrated scanning protocol for multimodal functional OCT.Biomedical optics express · 2025Article
- Noninvasive Bedside Approaches for Assessing Microvascular Dysfunction.Journal of vascular research · 2025Review
- LS-Net: lightweight segmentation network for dermatological epidermal segmentation in optical coherence tomography imaging.Biomedical optics express · 2024Article
- Advances in the Application of Noninvasive Skin Imaging Techniques in Acne Scars.American journal of clinical dermatology · 2024Review
- Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris.Dermatology and therapy · 2024Article
- Rapid measurement of epidermal thickness in OCT images of skin.Scientific reports · 2024Article
- Semisupervised representative learning for measuring epidermal thickness in human subjects in optical coherence tomography by leveraging datasets from rodent models.Journal of biomedical optics · 2022Article
- A Comparative Study of Dermatoscopic Features of Acne-related Postinflammatory Hyperpigmentation in Facial and Nonfacial Areas in Asian Patients.The Journal of clinical and aesthetic dermatology · 2022Article
- Quantification metrics for telangiectasia using optical coherence tomography.Scientific reports · 2022Article
- Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography.Advances in experimental medicine and biology · 2021Review
- Imaging in Chronic Wound Diagnostics.Advances in wound care · 2020Review
- Microvascular imaging of the skin.Physics in medicine and biology · 2019Review
- OCT-based microangiography for reactive hyperaemia assessment within residual limb skin of people with lower limb loss.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2018Article
- Improved speckle contrast optical coherence tomography angiography.American journal of translational research · 2018Article
- Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements.Journal of biomedical optics · 2017Article
- Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid.Journal of biomedical optics · 2017Article
- Repeatability of vessel density measurement in human skin by OCT-based microangiography.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2017Article
- Optical coherence tomography based angiography [Invited].Biomedical optics express · 2017Review
- Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe forBiomedical optics express · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveAcne is a common skin disease that often leads to scarring. Collagen and other tissue damage from the inflammation of acne give rise to permanent skin texture and microvascular changes. In this study, we demonstrate the capabilities of optical coherence tomography-based microangiography in detecting high-resolution, three-dimensional structural, and microvascular features of in vivo human facial skin during acne lesion initiation and scar development. MATERIALS AND
methodsA real time swept source optical coherence tomography system is used in this study to acquire volumetric images of human skin. The system operates on a central wavelength of 1,310 nm with an A-line rate of 100 kHz, and with an extended imaging range (∼12 mm in air). The system uses a handheld imaging probe to image acne lesion on a facial skin of a volunteer. We utilize optical microangiography (OMAG) technique to evaluate the changes in microvasculature and tissue structure.
resultsThanks to the high sensitivity of OMAG, we are able to image microvasculature up to capillary level and visualize the remodeled vessels around the acne lesion. Moreover, vascular density change derived from OMAG measurement is provided as an alternative biomarker for the assessment of human skin diseases. In contrast to other techniques like histology or microscopy, our technique made it possible to image 3D tissue structure and microvasculature up to 1.5 mm depth in vivo without the need of exogenous contrast agents.
conclusionsThe presented results are promising to facilitate clinical trials aiming to treat acne lesion scarring, as well as other prevalent skin diseases, by detecting cutaneous blood flow and structural changes within human skin in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.