Evidence map›Paper›PMID 25740303›Full record

ArticleChemical senses2015

Taste bud leptin: sweet dampened at initiation site.

Susan P Travers, Marion E Frank

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical senses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Susan P TraversDivision of Biosciences, College of Dentistry, The Ohio State University, 305W 12th Avenue, Columbus, OH 43210, USA and travers.3@osu.edu.
Marion E FrankDepartment of Oral Health, UCONN Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
The Ohio State University · USUConn Health · US

Funding

PERIPHERAL GUSTATORY PROCESSINGR01DC004099 · NIDCD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI FRANK, MARION ELIZABETH · 1999 to 2010
$3.2M
NIDCD NIH HHS DC004099NIDCD NIH HHS R01 DC726315
6 · The paper itself

Abstract

The intriguing observation that leptin decreases sweet-evoked peripheral gustatory responses has aroused much interest (Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y. 2000. Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci U S A. 97(20):11044-11049.) due to its implied importance in controlling appetite. The effects of this anorexic hormone, however, appear more conditional than originally believed. In this issue of Chemical Senses, a careful study by Glendinning and colleagues, find no effects of leptin on sweet-evoked chorda tympani responses, whereas an equally careful study by Meredith and colleagues, find decreased release of ATP and increased release of 5-HT from taste buds in response to sweet stimuli.

Indexed as

AnimalsCalciumFemaleLeptinMaleNeurotransmitter AgentsSweetening AgentsTasteTaste BudsTongueCalciumLeptinNeurotransmitter AgentsSweetening Agentschorda tympanileptintaste bud

Identifiers

PMID25740303
PMCPMC4481583
OpenAlexW2335271762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.