ArticleBrain : a journal of neurology2015
Neural detection of complex sound sequences in the absence of consciousness.
Article in Brain : a journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Computational predictive processing models of consciousness: a systematic review of non-invasive brain signal analysis in disorders of consciousness.Frontiers in computational neuroscience · 2026Pooled it
- Multisensory integration in peripersonal space indexes consciousness states in sleep and disorders of consciousness.Cell reports. Medicine · 2026Article
- Repetitions trigger illusory awareness in implicit statistical learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Illuminating consciousness.Frontiers in psychology · 2026Review
- Bridging subjective and neural state transitions in the rubber hand illusion: a neurophenomenological study.Neuroscience of consciousness · 2026Article
- Reconstructing Covert Consciousness: Neural Decoding as a Novel Consciousness Assessment.Neurology · 2025Review
- Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients.Brain sciences · 2025Article
- Complex auditory regularity processing across levels of consciousness in coma: Stage 1 Registered Report.Brain communications · 2025Article
- Cardio-audio synchronization elicits neural and cardiac surprise responses in human wakefulness and sleep.Communications biology · 2024Article
- Communication in the ICU: An Unintended Nocebo Effect?Journal of patient experience · 2024Article
- Consciousness in the cradle: on the emergence of infant experience.Trends in cognitive sciences · 2023Review
- Tracking auditory mismatch negativity responses during full conscious state and coma.Frontiers in neurology · 2023Article
- Prognostication after cardiac arrest: how EEG and evoked potentials may improve the challenge.Annals of intensive care · 2022Review
- Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2022Review
- Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors.Brain sciences · 2021Article
- Consciousness and complexity: a consilience of evidence.Neuroscience of consciousness · 2021Review
- Automatic Sensory Predictions: A Review of Predictive Mechanisms in the Brain and Their Link to Conscious Processing.Frontiers in human neuroscience · 2021Review
- Importance, limits and caveats of the use of "disorders of consciousness" to theorize consciousness.Neuroscience of consciousness · 2021Review
- Insights into human cognition from intracranial EEG: A review of audition, memory, internal cognition, and causality.Journal of neural engineering · 2020Review
- The brain tracks auditory rhythm predictability independent of selective attention.Scientific reports · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural response to a violation of sequences of identical sounds is a typical example of the brain's sensitivity to auditory regularities. Previous literature interprets this effect as a pre-attentive and unconscious processing of sensory stimuli. By contrast, a violation to auditory global regularities, i.e. based on repeating groups of sounds, is typically detectable when subjects can consciously perceive them. Here, we challenge the notion that global detection implies consciousness by testing the neural response to global violations in a group of 24 patients with post-anoxic coma (three females, age range 45-87 years), treated with mild therapeutic hypothermia and sedation. By applying a decoding analysis to electroencephalographic responses to standard versus deviant sound sequences, we found above-chance decoding performance in 10 of 24 patients (Wilcoxon signed-rank test, P < 0.001), despite five of them being mildly hypothermic, sedated and unarousable. Furthermore, consistently with previous findings based on the mismatch negativity the progression of this decoding performance was informative of patients' chances of awakening (78% predictive of awakening). Our results show for the first time that detection of global regularities at neural level exists despite a deeply unconscious state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.