ReviewJournal of endocrinological investigation2015
Total thyroid ablation in Graves' orbitopathy.
Review in Journal of endocrinological investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Relation between therapy options for Graves' disease and the course of Graves' ophthalmopathy: a systematic review and meta-analysis.Journal of endocrinological investigation · 2016Pooled it
- Beneficial effect of low-dose radioiodine ablation for Graves' orbitopathy: results of a retrospective study.Journal of endocrinological investigation · 2021Article
- Occurrence of Graves' hyperthyroidism and Graves' orbitopathy after fine-needle aspiration biopsy of thyroid nodules.Journal of endocrinological investigation · 2020Article
- Serum antibodies against the insulin-like growth factor-1 receptor (IGF-1R) in Graves' disease and Graves' orbitopathy.Journal of endocrinological investigation · 2019Article
- Cholesterol Serum Levels and Use of Statins in Graves' Orbitopathy: A New Starting Point for the Therapy.Frontiers in endocrinology · 2019Review
- Relationship between serum cholesterol and Graves' orbitopathy (GO): a confirmatory study.Journal of endocrinological investigation · 2018Article
- Antioxidant effects of β-carotene, but not of retinol and vitamin E, in orbital fibroblasts from patients with Graves' orbitopathy (GO).Journal of endocrinological investigation · 2018Article
- Association of T and B Cells Infiltrating Orbital Tissues With Clinical Features of Graves Orbitopathy.JAMA ophthalmology · 2018Article
- Use of low-dose radioiodine ablation for Graves' orbitopathy: results of a pilot, perspective study in a small series of patients.Journal of endocrinological investigation · 2018Article
- Occurrence of Graves' Orbitopathy and Graves' Hyperthyroidism after a Trauma to the Eye.European thyroid journal · 2018Article
- Article
- Natural history of graves' orbitopathy after treatment.Endocrine · 2017Article
- Comparative analysis of radioactive iodine versus thyroidectomy for definitive treatment of Graves disease.Surgery · 2017Article
- Acute liver damage following intravenous glucocorticoid treatment for Graves' ophthalmopathy.Endocrine · 2016Review
- Management of hyperthyroidism due to Graves' disease: frequently asked questions and answers (if any).Journal of endocrinological investigation · 2016Review
- Safety of total thyroid ablation in patients with Graves' orbitopathy.Journal of endocrinological investigation · 2016Article
- Prospective, systematically recorded mycophenolate safety data in Graves' orbitopathy.Journal of endocrinological investigation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graves' orbitopathy (GO) is an autoimmune condition almost always associated with autoimmune thyroid disease, especially Graves' disease (GD). According to the most widely accepted model, the autoantigens responsible for GO would include molecules expressed by thyroid epithelial cells that are present also in orbital tissues. The high likelihood that the etiologies of GO and of the underlying autoimmune thyroid diseases are somehow linked is confirmed by the very close relationship between GO, the onset and the course of Graves' diseases, the size of the thyroid gland, and most importantly, thyroid function and thyroid treatment. Based on these considerations, it has been proposed that complete removal of thyroid antigens and of thyroid infiltrating lymphocytes, the so-called total thyroid ablation (TTA), may be followed by an attenuation of the immune reaction against orbital antigens, and ultimately by an amelioration of GO. The possibility that TTA, achieved by near total thyroidectomy followed by radioiodine, may be beneficial for GO was initially suggested by two retrospective studies and more recently by two prospective, randomized clinical trials conducted in patients with moderate GO treated with intravenous glucocorticoids. Although there seemed to be no difference in the long term, compared with near total thyroidectomy alone TTA was associated with a shorter time required for GO to improve, or anyway to reach its best possible outcome, and with a lesser requirement for additional treatments for GO to improve. Whether this is sufficient to offer ablation to patients remains a matter of discussion. At present, this procedure could be offered only to patients scheduled to thyroidectomy and glucocorticoid treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.