ArticleAmerican journal of human genetics1989
Chromosome-specific alpha satellite DNA from the centromere of human chromosome 16.
Article in American journal of human genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026Review
- Tigerfish designs oligonucleotide-based in situ hybridization probes targeting intervals of highly repetitive DNA at the scale of genomes.Nature communications · 2024Article
- Centromere Identity and the Regulation of Chromosome Segregation.Frontiers in cell and developmental biology · 2022Review
- Classification and monomer-by-monomer annotation dataset of suprachromosomal family 1 alpha satellite higher-order repeats in hg38 human genome assembly.Data in brief · 2019Article
- Rapid molecular assays to study human centromere genomics.Genome research · 2017Article
- A unique chromatin complex occupies young α-satellite arrays of human centromeres.Science advances · 2015Article
- Consensus higher order repeats and frequency of string distributions in human genome.Current genomics · 2007Article
- Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas.The American journal of pathology · 2002Article
- Preferential occurrence of breast carcinomas with loss of chromosome 16q and der (16) t (1;16) / der (1;16) in middle-aged patients with hyperplasia of mammary glands.Japanese journal of cancer research : Gann · 2000Article
- Replication timing of homologous alpha-satellite DNA in Roberts syndrome.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Chromosome band 16q24 is frequently deleted in human gastric cancer.British journal of cancer · 1999Article
- Detection of numerical and structural alterations and fusion of chromosomes 16 and 1 in low-grade papillary breast carcinoma by fluorescence in situ hybridization.The American journal of pathology · 1997Article
- Scaffold attachment regions in centromere-associated DNA.Chromosoma · 1996Article
- Aneuploidy in human sperm: the use of multicolor FISH to test various theories of nondisjunction.American journal of human genetics · 1996Article
- Fluorescence in situ hybridization on paraffin-embedded abortion material as a means of retrospective chromosome analysis.Human genetics · 1994Article
- Hypomethylation of classical satellite DNA and chromosome instability in lymphoblastoid cell lines.Human genetics · 1993Article
- ICF syndrome with variable expression in sibs.Journal of medical genetics · 1993Article
- Characterisation of a boundary between satellite III and alphoid sequences on human chromosome 10.Nucleic acids research · 1992Article
- Article
- Characterization and mapping of human genes encoding zinc finger proteins.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To examine the molecular organization of DNA sequences located in the centromeric region of human chromosome 16 we have isolated and characterized a chromosome 16-specific member of the alpha satellite DNA family. The probe obtained is specific for the centromere of chromosome 16 by somatic cell hybrid analysis and by fluorescence in situ hybridization and allows detection of specific hybridizing domains in interphase nuclei. Nucleotide sequence analysis indicates that this class of chromosome 16 alpha satellite (D16Z2) is organized as a series of diverged 340-bp dimers arranged in a tandem array of 1.7-kb higher-order repeat units. As measured by pulsed-field gel electrophoresis, the total D16Z2 array spans approximately 1,400-2,000 kb of centromeric DNA. These sequences are highly polymorphic, both by conventional agarose-gel electrophoresis and by pulsed-field gel electrophoresis. Investigation of this family of alpha satellite should facilitate the further genomic, cytogenetic, and genetic analysis of chromosome 16.
Indexed as
Identifiers
2573999PMC1683467W157686390What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.