ArticleThe Journal of reproduction and development2015
Let-7-mediated suppression of mucin 1 expression in the mouse uterus during embryo implantation.
Article in The Journal of reproduction and development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- Proteomic profiling of isolated mouse endometrial epithelial cells reveals coordinated redox and endoplasmic reticulum stress-associated pathways during uterine receptivity.Veterinary world · 2026Article
- Regulatory Effect of circRNA3890 on the Establishment of Receptive Endometrium in Dairy Goats.Animals : an open access journal from MDPI · 2026Article
- CircRNAs-Potential Diagnostic Biomarkers and Therapeutic Targets for Receptive and Cancerous Endometrium.Epigenomes · 2025Review
- Estrogen-Regulated Proline-Rich Acidic Protein 1 in Endometrial Epithelial Cells Affects Embryo Implantation by Regulating Mucin 1 in Mice.Biomolecules · 2025Article
- MicroRNA participates in embryo implantation by modulating endometrial tolerance in sows during peri-implantation period.Frontiers in endocrinology · 2025Review
- MicroRNAs, endometrial receptivity and molecular pathways.Reproductive biology and endocrinology : RB&E · 2024Review
- Autologous hGMSC-Derived iPS: A New Proposal for Tissue Regeneration.International journal of molecular sciences · 2024Article
- Serum exosomal miR-192 serves as a potential detective biomarker for early pregnancy screening in sows.Animal bioscience · 2023Article
- Uterine Flushing Fluid-Derived Let-7b Targets CXCL10 to Regulate Uterine Receptivity in Goats during Embryo Implantation.International journal of molecular sciences · 2023Article
- miR-1246 is implicated as a possible candidate for endometrium remodelling facilitating implantation in buffalo (Bubalus bubalis).Veterinary medicine and science · 2023Article
- Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality.Journal of animal science and biotechnology · 2022Article
- MicroRNAs in the Regulation of Endometrial Receptivity for Embryo Implantation.International journal of molecular sciences · 2022Review
- Role of endometrial microRNAs in repeated implantation failure (mini-review).Frontiers in cell and developmental biology · 2022Review
- The effect of dexamethasone on uterine receptivity, mediated by the ERK1/2-mTOR pathway, and the implantation window: An experimental study.International journal of reproductive biomedicine · 2022Article
- A comprehensive analysis of miRNA/isomiRs profile of hydrosalpinx patients with interventional ultrasound sclerotherapy.PloS one · 2022Article
- Role of miRNAs in Normal Endometrium and in Endometrial Disorders: Comprehensive Review.Journal of clinical medicine · 2021Review
- Association of miRNA-145 with the occurrence and prognosis of hydrosalpinx-induced defective endometrial receptivity.Bosnian journal of basic medical sciences · 2021Article
- Understanding the Impact of Uterine Fibroids on Human Endometrium Function.Frontiers in cell and developmental biology · 2021Review
- Calcitonin administration improves endometrial receptivity via regulation of LIF, Muc-1 and microRNA Let-7a in mice.Journal of cellular physiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucin 1 (Muc1) is an integral transmembrane mucin glycoprotein expressed on the apical surface of most epithelia. It is considered to be a barrier to the regulation of embryo implantation by inhibiting attachment of the embryo to the endometrium. Therefore, loss of Muc1 on the surface of uterine epithelial cells is necessary for embryo implantation. Studies have demonstrated that microRNAs (miRNAs) play a key role in enhancing embryo implantation in mammals. In this study, we investigated the regulatory role of two miRNAs (let-7a and let-7b) on the expression of Muc1 in mouse uteri during implantation. Western blotting indicated that Muc1 expression was highest on day1 of pregnancy and constantly decreased thereafter until day 4. In contrast to Muc1 expression, increased expression of let-7a and let-7b was evident on day 4 of pregnancy as measured by real-time reverse transcription-polymerase chain reaction (real-time RT-PCR). We demonstrated direct binding of let-7a and let-7b to the 3'untranslated region of muc1. Furthermore, Muc1 expression was suppressed after transfection of mouse uterine epithelial cells isolated from day 1 of pregnancy with let-7a and let-7b. In summary, the present study provides evidence that Muc1 is a direct target of let-7a and let-7b. Additionally, the current study suggests that miRNAs are novel targets which can be used to facilitate a successful pregnancy and repair implantation failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.